Insulin antibody (INS)

Details for Product anti-INS Antibody No. ABIN6297596
Target
Reactivity
Human, Mouse, Rat
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154
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8
5
5
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3
2
2
2
2
1
1
1
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1
Host
Mouse
206
108
23
3
2
1
Clonality
Monoclonal
Conjugate
This Insulin antibody is un-conjugated
27
15
14
5
5
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5
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5
5
5
5
5
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4
4
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3
3
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1
Application
Immunofluorescence (IF), Immunohistochemistry (IHC)
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40
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5
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Options
Purpose Mouse anti-Human/Mouse/Rat Insulin Antibody [Sodium Azide Free]
Immunogen Recombinant INS protein was used as the immunogen for the Insulin antibody.
Specificity Cytoplasmic
Purification Recombinant INS protein was used as the immunogen for the Insulin antibody.
Target
Alternative Name Insulin (INS Antibody Abstract)
Background

Target Description: After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. [RefSeq]

Gene Symbol: INS

Gene ID 3630
UniProt P01308
Pathways NF-kappaB Signaling, RTK Signaling, Positive Regulation of Peptide Hormone Secretion, Peptide Hormone Metabolism, Hormone Activity, Carbohydrate Homeostasis, ER-Nucleus Signaling, Regulation of Carbohydrate Metabolic Process, Feeding Behaviour, Autophagy, Negative Regulation of intrinsic apoptotic Signaling, Brown Fat Cell Differentiation, Positive Regulation of fat Cell Differentiation
Application Notes Immunofluorescence: 1-2 μg/mL
Immunohistochemistry (FFPE): 0.1-0.2 μg/mL for 30 min at RT (1)
Prediluted format: incubate for 30 min at RT (2)
Restrictions For Research Use only
Buffer In 1X PBS, BSA free, sodium azide free
Preservative Azide free
Storage 4 °C,-20 °C
Storage Comment 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.