Insulin antibody (INS)

Details for Product anti-INS Antibody No. ABIN6297596
Antigen
  • ins1
  • xins
  • ins1-a
  • Insulin
  • IDDM2
  • ILPR
  • IRDN
  • MODY10
  • AA986540
  • Ins-2
  • InsII
  • Mody
  • Mody4
  • proinsulin
  • zgc:109842
  • insulin
  • insulin precursor
  • insulin II
  • preproinsulin
  • ins
  • PIN
  • INS
  • Ins
  • INS-IGF2
  • Ins2
Reactivity
Human, Mouse (Murine), Rat (Rattus)
722
288
254
236
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120
11
9
6
6
6
4
3
2
2
2
2
2
1
1
1
1
1
1
Host
Mouse
556
208
48
4
2
1
Clonality
Monoclonal
Conjugate
This Insulin antibody is un-conjugated
39
29
24
15
13
13
8
8
8
8
8
8
5
5
5
5
5
5
5
5
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5
5
5
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2
1
Application
Immunofluorescence (IF), Immunohistochemistry (IHC)
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21
20
6
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Options
Purpose Mouse anti-Human/Mouse/Rat Insulin Antibody [Sodium Azide Free]
Immunogen Recombinant INS protein was used as the immunogen for the Insulin antibody.
Specificity Cytoplasmic
Purification Recombinant INS protein was used as the immunogen for the Insulin antibody.
Plasmids, Primers & others Plasmids, Primers & others Insulin products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name Insulin (INS Antibody Abstract)
Background

Target Description: After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. [RefSeq]

Gene Symbol: INS

Gene ID 3630
UniProt P01308
Pathways NF-kappaB Signaling, RTK Signaling, Positive Regulation of Peptide Hormone Secretion, Peptide Hormone Metabolism, Hormone Activity, Carbohydrate Homeostasis, ER-Nucleus Signaling, Regulation of Carbohydrate Metabolic Process, Feeding Behaviour, Autophagy, Negative Regulation of intrinsic apoptotic Signaling, Brown Fat Cell Differentiation, Positive Regulation of fat Cell Differentiation
Application Notes Immunofluorescence: 1-2 μg/mL
Immunohistochemistry (FFPE): 0.1-0.2 μg/mL for 30 min at RT (1)
Prediluted format: incubate for 30 min at RT (2)
Restrictions For Research Use only
Buffer In 1X PBS, BSA free, sodium azide free
Preservative Azide free
Storage 4 °C,-20 °C
Storage Comment 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
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