beta-2 Microglobulin antibody (beta-2-Microglobulin)

Details for Product anti-B2M Antibody No. ABIN6297657
Antigen
  • Ly-m11
  • beta2-m
  • beta2m
  • bwm
  • wu:fa94c05
  • wu:fb10a09
  • b2m-W01
  • b2m-W03
  • b2m-Z01
  • b2m-Z02
  • b2m-Z03
  • B2M
  • b2m
  • B2MG
  • b-2-m
  • beta-2-microglobulin
  • beta-2 microglobulin
  • beta-2-microglobulin S homeolog
  • B2M
  • B2m
  • b2m
  • b2m.S
Reactivity
Human, Non-Human Primate
519
119
69
66
16
9
6
5
3
2
2
2
2
1
1
1
1
1
1
Host
Mouse
354
201
15
12
9
2
1
Clonality
Monoclonal
Conjugate
This beta-2 Microglobulin antibody is un-conjugated
50
34
24
23
13
8
7
5
5
5
5
5
5
5
5
5
5
5
5
5
5
5
5
5
5
5
1
1
1
1
1
Application
Flow Cytometry (FACS), Immunofluorescence (IF)
293
261
188
185
136
97
68
45
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43
32
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24
13
8
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8
2
2
2
2
1
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1
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Options
Purpose Mouse anti-Human/non-Human primates Beta-2 Microglobulin Antibody [Sodium Azide Free]
Immunogen Soluble beta 2 microglobulin was used as the immunogen for the Beta-2 Microglobulin antibody.
Specificity Cytoplasmic
Purification Soluble beta 2 microglobulin was used as the immunogen for the Beta-2 Microglobulin antibody.
Plasmids, Primers & others Plasmids, Primers & others beta-2 Microglobulin products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name Beta-2-microglobulin (B2M Antibody Abstract)
Background

Target Description: The antibody recognizes the hidden determinant of beta-2 microglobulin (i.e. binding to its determinant is available only when the chain is separated from the HLA heavy chain). Beta-2 microglobulin is a 12KDa protein with a pI of 5.6. Serum beta-2 microglobulin levels are a reflection of cell turnover. Levels rise with fever, inflammation, and infection. Increased serum levels are also seen in B-cell malignancies and in renal failure and may indicate a worse prognosis for patients with early-stage Hodgkin's lymphoma. In urine, increased levels are seen in proximal renal tubular disease as well as renal transplant rejection. Beta-2 microglobulin levels can rise either because its rate of synthesis has increased (e.g. in AIDS, malignant monoclonal plasma cell dyscrasia, solid tumours and autoimmune disease) or because of impaired renal filtration (e.g. due to renal insufficiency, graft rejection or nephrotoxicity induced by post-transplantation immunosuppressive therapy).

Gene Symbol: B2M///CDABP0092///HDCMA22P

Gene ID 567
UniProt P61769
Pathways TCR Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
Application Notes Flow Cytometry: 0.5-1 μg/million cells in 0.1ml
Immunofluorescence: 0.5-1 μg/mL
Restrictions For Research Use only
Buffer In 1X PBS, BSA free, sodium azide free
Preservative Azide free
Storage 4 °C,-20 °C
Storage Comment 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
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