beta-2 Microglobulin antibody (beta-2-Microglobulin) (AA 21-100)

Details for Product anti-B2M Antibody No. ABIN1724930
Antigen
Epitope
AA 21-100
21
21
12
8
7
6
6
5
3
1
1
1
1
1
1
1
1
1
Reactivity
Human
486
100
67
64
16
9
6
4
3
2
2
2
1
1
1
1
1
1
Host
Mouse
322
195
15
11
9
2
1
Clonality (Clone)
Monoclonal ()
Conjugate
This beta-2 Microglobulin antibody is un-conjugated
50
34
18
18
8
5
5
5
5
5
5
5
5
5
5
5
5
5
5
5
5
5
5
5
3
2
1
1
1
1
1
Application
Flow Cytometry (FACS), Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
264
249
183
159
125
96
60
43
40
33
32
24
19
13
8
8
8
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Options
Immunogen Purified recombinant fragment of human B2M (AA 21-100) expressed in E. Coli.
Clone 3G5H8
Isotype IgG2a
Purification Purified
Antigen
Alternative Name B2M (B2M Antibody Abstract)
Background This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia. ,
Molecular Weight 13.7 kDa
Gene ID 567
HGNC 567
Pathways TCR Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
Application Notes ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, FCM: 1:200 - 1:400
Restrictions For Research Use only
Format Liquid
Buffer PBS with 0.05 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C,-20 °C
Storage Comment 4°C, -20°C for long term storage
Supplier Images
Image no. 1 for anti-beta-2-Microglobulin (B2M) (AA 21-100) antibody (ABIN1724930) Immunohistochemical analysis of paraffin-embedded ovarian cancer tissues using B2M mo...
Image no. 2 for anti-beta-2-Microglobulin (B2M) (AA 21-100) antibody (ABIN1724930) Immunohistochemical analysis of paraffin-embedded esophageal cancer tissues using B2M...
Product cited in: Bernal, Ruiz-Cabello, Concha, Paschen, Garrido: "Implication of the ?2-microglobulin gene in the generation of tumor escape phenotypes." in: Cancer immunology, immunotherapy : CII, Vol. 61, Issue 9, pp. 1359-71, 2012 (PubMed).

Hermansen, Hummelshøj, Lundsgaard, Hornum, Keller, Fleckner, Fox, Poulsen, Jacobsen: "Increased serum ?2-microglobulin is associated with clinical and immunological markers of disease activity in systemic lupus erythematosus patients." in: Lupus, Vol. 21, Issue 10, pp. 1098-104, 2012 (PubMed).