CD36 antibody (CD36 Molecule (thrombospondin Receptor))

Details for Product anti-CD36 Antibody No. ABIN6297679
Target
Reactivity
Human
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Host
Mouse
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Clonality
Monoclonal
Conjugate
This CD36 antibody is un-conjugated
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Application
Flow Cytometry (FACS), Functional Studies (Func), Immunofluorescence (IF)
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Options
Purpose Mouse anti-Human CD36 Antibody [Sodium Azide Free]
Immunogen Stimulated human leukocytes were used as the immunogen for the CD36 antibody.
Specificity Cell surface
Purification Stimulated human leukocytes were used as the immunogen for the CD36 antibody.
Target
Alternative Name Platelet glycoprotein 4 (CD36 Antibody Abstract)
Background

Target Description: CD36 binds to collagen, thrombospondin, anionic phospholipids and oxidized low-density lipoprotein (oxLDL). May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Receptor for thombospondins, THBS1 AND THBS2, mediating their antiangiogenic effects. As a coreceptor for TLR4-TLR6 heterodimer, promotes inflammation in monocytes/macrophages. Upon ligand binding, such as oxLDL or amyloid-beta 42, rapidly induces the formation of a heterodimer of TLR4 and TLR6, which is internalized and triggers inflammatory response, leading to NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion. [UniProt]

Gene Symbol: CD36///GP3B///GP4

Gene ID 948
UniProt P16671
Pathways TLR Signaling, Peptide Hormone Metabolism, Response to Growth Hormone Stimulus, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Regulation of Lipid Metabolism by PPARalpha, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Hepatitis C, Toll-Like Receptors Cascades, Lipid Metabolism
Application Notes Functional Activity (Order SAF formulation) (1)
Flow Cytometry: 0.5-1 μg/million cells in 0.1ml
Immunofluorescence: 0.5-1 μg/mL
Restrictions For Research Use only
Buffer In 1X PBS, BSA free, sodium azide free
Preservative Azide free
Storage 4 °C,-20 °C
Storage Comment 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.