SHC1 antibody (SHC (Src Homology 2 Domain Containing) Transforming Protein 1)

Details for Product anti-SHC1 Antibody No. ABIN6298167
Antigen
  • SHC1
  • SHC
  • SHCA
  • P66shc
  • si:dkey-246i14.4
  • wu:fc10h03
  • shc
  • p66shc
  • Shc
  • ShcA
  • p66
  • SHC adaptor protein 1
  • Shc1p
  • squalene--hopene cyclase
  • SHC (Src homology 2 domain containing) transforming protein 1
  • SHC (Src homology 2 domain containing) transforming protein 1 L homeolog
  • src homology 2 domain-containing transforming protein C1
  • SHC1
  • shc1
  • Shc1
  • shc1.L
Reactivity
Human, Mouse (Murine), Rat (Rattus)
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Host
Rabbit
299
47
Clonality
Polyclonal
Conjugate
This SHC1 antibody is un-conjugated
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10
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Application
247
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66
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Options
Purpose Rabbit Anti-Shc (Ab-349) Antibody,
Plasmids, Primers & others Plasmids, Primers & others SHC1 products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name Shc (SHC1 Antibody Abstract)
Background

Target Description: Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis.

Gene Symbol: SHC1

Gene ID 6464
UniProt P29353
Pathways RTK Signaling, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, ER-Nucleus Signaling, Signaling Events mediated by VEGFR1 and VEGFR2
Restrictions For Research Use only
Storage 4 °C,-20 °C
Storage Comment 2-8°C (short-term), -20°C (long-term)
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