Shiga Toxin 1 & 2 (Stx-1, Stx-2) antibody

Catalog No. ABIN648008

The Mouse anti- antibody has been validated for . It is suitable to detect in samples from E. coli.

Quick Overview for Shiga Toxin 1 & 2 (Stx-1, Stx-2) antibody (ABIN648008)

Target: Shiga Toxin 1 & 2 (Stx-1, Stx-2)

Reactivity: E. coli

Host: Mouse

Conjugate: Un-conjugated

Application: Please inquire

Product Details

Specificity: Reacts with Escherichia coli (E. coli) Shigatoxin (STX) 1 and 2

Characteristics: Mouse Anti-E. coli STX 1 & 2

Purification: Purified

Isotype: IgG

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Reconstitute with 1ml deionized water.

Concentration: 1 mg/ml (prior to lyophilization)

Buffer: Lyophilized from 5mM Phosphate buffer, pH 7.2 - 7.4

Storage: 4 °C

Target Details

Target: Shiga Toxin 1 & 2 (Stx-1, Stx-2)

Background: Monoclonal Antibody to Escherichia coli (E. coli) Shigatoxin (STX) 1 and 2, pooled IgGThe baculovirus protein p35 inhibits virally induced apoptosis of invertebrate and mammalian cells and may function to impair the clearing of virally infected cells by the host's immune system. This is accomplished at least in part by its ability to block both TNF- and FAS-mediated apoptosis through the inhibition of the ICE family of serine proteases. Two mammalian homologs of baculovirus p35, referred to as inhibitor of apoptosis protein (IAP) 1 and 2, share an amino terminal baculovirus IAP repeat (BIR) motif and a carboxy terminal RING finger. Although the c-IAPs do not directly associate with the TNF receptor (TNF-R), they efficiently block TNF-mediated apoptosis through their interaction with the downstream TNF-R effectors, TRAF1 and TRAF2. Additional IAP family members include ILP (for IAP-like protein) and survivin. ILP inhibits activated caspase-3, leading to the resistance of FAS-mediated apoptosis. Survivin (also designated TIAP) is expressed during the G2/M phase of the cell cycle and associates with microtublules of the mitotic spindle. Increased caspase-3 activity is detected when a disruption of survivin-microtubule interactions occurs.