TUBB3 antibody (AA 36-63)

Catalog No. ABIN651938

Product Details anti-TUBB3 Antibody

Target: TUBB3 (Tubulin, beta 3 (TUBB3))

Binding Specificity: AA 36-63

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TUBB3 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Predicted Reactivity: B, Pr, Rat, C

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This TUBB3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 36-63 amino acids of human TUBB3.

Clone: RB21098

Isotype: IgG

Application Details

Application Notes: WB: 1:1000. WB: 1:1000. WB: 1:1000. IHC-P: 1:10~50. FC: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-TUBB3 antibody (ABIN651938)

Kazmierczak, Kazmierczak, Peng, Harris, Shah, Puel, Lenoir, Franco, Schwander: "Pejvakin, a Candidate Stereociliary Rootlet Protein, Regulates Hair Cell Function in a Cell-Autonomous Manner." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 37, Issue 13, pp. 3447-3464, (2017) (PubMed).

Jeong, Martchenko, Cohen: "Calpain-dependent cytoskeletal rearrangement exploited for anthrax toxin endocytosis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 110, Issue 42, pp. E4007-15, (2013) (PubMed).

Target Details for TUBB3

Target: TUBB3 (Tubulin, beta 3 (TUBB3))

Alternative Name: TUBB3 (TUBB3 Products)

Background: Beta III tubulin is abundant in the central and peripheral nervous systems (CNS and PNS) where it is prominently expressed during fetal and postnatal development. As exemplified in cerebellar and sympathoadrenal neurogenesis, the distribution of beta III is neuron-associated, exhibiting distinct temporospatial gradients according to the regional neuroepithelia of origin. However, transient expression of this protein is also present in the subventricular zones of the CNS comprising putative neuronal- and/or glial precursor cells, as well as in Kulchitsky neuroendocrine cells of the fetal respiratory epithelium. This temporally restricted, potentially non-neuronal expression may have implications in the identification of presumptive neurons derived from embryonic stem cells.

Molecular Weight: 50433

Gene ID: 10381

NCBI Accession: NP_001184110, NP_006077

UniProt: Q13509

Pathways: Microtubule Dynamics, M Phase