COX10 antibody (C-Term)

Catalog No. ABIN654671

The Rabbit Polyclonal anti-COX10 antibody has been validated for WB, FACS and IHC (p). It is suitable to detect COX10 in samples from Human.

Quick Overview for COX10 antibody (C-Term) (ABIN654671)

Target: COX10 (Cytochrome C Oxidase Assembly Homolog 10 (COX10))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This COX10 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB24307

Product Details anti-COX10 Antibody

Binding Specificity: AA 383-410, C-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This COX10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 383-410 amino acids from the C-terminal region of human COX10.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:50~100. FC: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for COX10

Target: COX10 (Cytochrome C Oxidase Assembly Homolog 10 (COX10))

Alternative Name: COX10

Background: Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes heme A:farnesyltransferase, which is not a structural subunit but required for the expression of functional COX and functions in the maturation of the heme A prosthetic group of COX. This protein is predicted to contain 7-9 transmembrane domains localized in the mitochondrial inner membrane. A gene mutation, which results in the substitution of a lysine for an asparagine (N204K), is identified to be responsible for cytochrome c oxidase deficiency. In addition, this gene is disrupted in patients with CMT1A (Charcot-Marie-Tooth type 1A) duplication and with HNPP (hereditary neuropathy with liability to pressure palsies) deletion.

Molecular Weight: 48910

Gene ID: 1352

NCBI Accession: NP_001294

UniProt: Q12887