Factor XI antibody (AA 281-307)

Catalog No. ABIN655515

This anti-Factor XI antibody is a Rabbit Polyclonal antibody detecting Factor XI in WB and IHC (p). Suitable for Human.

Quick Overview for Factor XI antibody (AA 281-307) (ABIN655515)

Target: Factor XI (F11) (Coagulation Factor XI (F11))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Factor XI antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB19294

Product Details anti-Factor XI Antibody

Binding Specificity: AA 281-307

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This F11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 281-307 amino acids from the Central region of human F11.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for Factor XI

Target: Factor XI (F11) (Coagulation Factor XI (F11))

Alternative Name: F11

Background: This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality. [provided by RefSeq].

Molecular Weight: 70109

Gene ID: 2160

NCBI Accession: NP_000119

UniProt: P03951