TGFBR2 antibody (N-Term)

Catalog No. ABIN655799

The Rabbit Polyclonal anti-TGFBR2 antibody has been validated for WB, IHC (p) and IF. It is suitable to detect TGFBR2 in samples from Human and Mouse. There is 1 publication available.

Quick Overview for TGFBR2 antibody (N-Term) (ABIN655799)

Target: TGFBR2 (Transforming Growth Factor, beta Receptor II (70/80kDa) (TGFBR2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TGFBR2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Clone: RB31405

Product Details anti-TGFBR2 Antibody

Binding Specificity: AA 13-40, N-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This TGFBR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 13-40 amino acids from the N-terminal region of human TGFBR2.

Isotype: Ig Fraction

Application Details

Application Notes: IF: 1:10~50. WB: 1:2000. WB: 1:2000. WB: 1:2000. WB: 1:2000. WB: 1:1000. WB: 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-TGFBR2 antibody (ABIN655799)

Liang, Li, Zhang, Cui, Quan, Yang: "The anti-fibrotic effects of microRNA-153 by targeting TGFBR-2 in pulmonary fibrosis." in: Experimental and molecular pathology, Vol. 99, Issue 2, pp. 279-285, (2015) (PubMed).

Target Details for TGFBR2

Target: TGFBR2 (Transforming Growth Factor, beta Receptor II (70/80kDa) (TGFBR2))

Alternative Name: TGFBR2

Background: This gene encodes a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. The encoded protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized.

Molecular Weight: 64568

Gene ID: 7048

NCBI Accession: NP_001020018, NP_003233

UniProt: P37173