beta Amyloid antibody (Amyloid beta)

Details for Product anti-Abeta Antibody No. ABIN6566498
Antigen
Reactivity
Human
155
38
27
9
6
5
5
4
3
2
2
1
1
1
1
1
1
Host
Rabbit
98
65
4
2
Clonality
Polyclonal
Conjugate
This beta Amyloid antibody is un-conjugated
11
4
2
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
114
94
56
38
33
32
21
16
11
5
5
3
2
1
1
1
1
1
1
Options
Immunogen Recombinant protein of human APP
Isotype IgG
Purification Affinity purification
Antigen
Alternative Name beta Amyloid (Abeta Antibody Abstract)
Background

Synonyms: A4 amyloid protein,A4,AAA,ABETA,ABPP,AD1,AICD-50,AICD-57,AICD-59,AID(50),AID(57),AID(59),Alzheimer disease amyloid protein,Amyloid beta (A4) precursor protein,Amyloid beta A4 protein,Amyloid beta protein,Amyloid intracellular domain 50,Amyloid intracellular domain 57,Amyloid intracellular domain 59,Amyloid precursor protein,APP,APPI,Beta amyloid peptide,Beta-amyloid precursor protein,Beta-APP40,Beta-APP42,C31,Cerebral vascular amyloid peptide,CTFgamma,CVAP,Gamma-CTF(50),Gamma-CTF(57),Gamma-CTF(59),peptidase nexin II,PN 2,PN II,PN-II,PN2,PreA4,Protease nexin II,Protease nexin-II,S-APP-alpha,S-APP-beta

Background: This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.

Molecular Weight

Observed_MW: 110kDa

Calculated_MW: 34kDa/72-86kDa

Gene ID 351
UniProt P05067
Application Notes WB 1:500 - 1:2000 IHC 1:50 - 1:200
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C. Avoid freeze / thaw cycles.
Supplier Images
Image no. 1 for anti-Amyloid beta (Abeta) antibody (ABIN6566498) Immunohistochemistry of paraffin-embedded human stomach using APP antibody.
Image no. 2 for anti-Amyloid beta (Abeta) antibody (ABIN6566498) Immunohistochemistry of paraffin-embedded human esophagus using APP antibody.
Image no. 3 for anti-Amyloid beta (Abeta) antibody (ABIN6566498) Western blot analysis of extracts of various cell lines, using APP antibody.