FASL antibody

Catalog No. ABIN6566520

This anti-FASL antibody is a Rabbit Polyclonal antibody detecting FASL in WB. Suitable for Human, Mouse and Rat.

Quick Overview for FASL antibody (ABIN6566520)

Target: FASL (Fas Ligand (TNF Superfamily, Member 6) (FASL))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FASL antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-FASL Antibody

Purification: Affinity purification

Immunogen: A synthetic peptide of human FASLG

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for FASL

Target: FASL (Fas Ligand (TNF Superfamily, Member 6) (FASL))

Alternative Name: FASLG

Background:

Synonyms: ALPS1B,Apoptosis (APO 1) antigen ligand 1,Apoptosis antigen ligand 1,Apoptosis antigen ligand,APT1LG1,APTL,CD178,CD178 antigen,CD95 ligand,CD95-L,CD95L,CD95L protein,Fas antigen ligand,Fas L,Fas ligand (TNF superfamily member 6),Fas ligand,FASL,Fasl Fas ligand (TNF superfamily member 6),FASLG,Generalized lymphoproliferative disease,Gld,soluble form,TNFL6,TNFSF6,Tumor necrosis factor (ligand) superfamily member 6,Tumor necrosis factor ligand superfamily member 6

Background: This gene is a member of the tumor necrosis factor superfamily. The primary function of the encoded transmembrane protein is the induction of apoptosis triggered by binding to FAS. The FAS/FASLG signaling pathway is essential for immune system regulation, including activation-induced cell death (AICD) of T cells and cytotoxic T lymphocyte induced cell death. It has also been implicated in the progression of several cancers. Defects in this gene may be related to some cases of systemic lupus erythematosus (SLE). Alternatively spliced transcript variants have been described.

Molecular Weight:

Observed_MW: 45kDa

Calculated_MW: 14kDa/31kDa

Gene ID: 356

UniProt: P48023

Pathways: Apoptosis, EGFR Signaling Pathway, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity