MAP2K2 antibody (Mitogen-Activated Protein Kinase Kinase 2)

Details for Product anti-MAP2K2 Antibody No. ABIN6566536
Antigen
Reactivity
Human, Mouse (Murine), Rat (Rattus)
315
179
143
11
9
4
3
2
1
Host
Rabbit
248
61
7
1
Clonality
Polyclonal
Conjugate
This MAP2K2 antibody is un-conjugated
20
15
14
7
7
7
7
7
7
7
7
7
2
2
2
2
2
Application
Immunohistochemistry (IHC), Western Blotting (WB)
244
116
107
43
39
34
27
20
16
15
7
6
5
1
Options
Immunogen A synthetic peptide of human MAP2K2
Isotype IgG
Purification Affinity purification
Antigen
Alternative Name MAP2K2 (MAP2K2 Antibody Abstract)
Background

Synonyms: Cardiofaciocutaneous syndrome,CFC syndrome,CFC4,Dual specificity mitogen activated protein kinase kinase 2,Dual specificity mitogen-activated protein kinase kinase 2,ERK activator kinase 2,FLJ26075,MAP kinase kinase 2,map2k2,MAPK / ERK kinase 2,MAPK/ERK kinase 2,MAPKK 2,MAPKK2,MEK 2,MEK2,Microtubule associated protein kinase kinase 2,Mitogen activated protein kinase kinase 2,Mitogen activated protein kinase kinase 2 p45,MKK 2,MKK2,MP2K2,OTTHUMP00000165826,OTTHUMP00000165827,PRKMK 2,PRKMK2

Background: The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene.

Molecular Weight

Observed_MW: 53kDa

Calculated_MW: 44kDa

Gene ID 5605
UniProt P36507
Pathways MAPK Signaling, RTK Signaling, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades, Signaling of Hepatocyte Growth Factor Receptor
Application Notes WB 1:500 - 1:2000 IHC 1:50 - 1:200
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C. Avoid freeze / thaw cycles.
Supplier Images
Image no. 1 for anti-Mitogen-Activated Protein Kinase Kinase 2 (MAP2K2) antibody (ABIN6566536) Immunohistochemistry of paraffin-embedded human kidney using MAP2K2 antibody.
Image no. 2 for anti-Mitogen-Activated Protein Kinase Kinase 2 (MAP2K2) antibody (ABIN6566536) Western blot analysis of extracts of mouse brain, using MAP2K2 antibody.