MUC1 antibody (Mucin 1, Cell Surface Associated)

Details for Product anti-MUC1 Antibody No. ABIN6566576
Antigen
Reactivity
Human, Mouse (Murine)
1109
165
71
16
7
6
5
4
4
3
3
2
1
Host
Rabbit
722
409
4
3
Clonality
Polyclonal
Conjugate
This MUC1 antibody is un-conjugated
60
42
29
29
25
24
11
11
11
11
11
11
11
11
11
11
11
11
11
10
10
10
10
10
10
3
3
3
3
3
2
2
Application
Western Blotting (WB)
535
450
424
362
314
282
122
115
53
47
44
39
39
33
23
14
10
9
6
5
4
3
2
2
Options
Immunogen Recombinant protein of human MUC1
Isotype IgG
Purification Affinity purification
Antigen
Alternative Name MUC1 (MUC1 Antibody Abstract)
Background

Synonyms: ADMCKD,ADMCKD1,Breast carcinoma associated antigen DF3,Breast carcinoma-associated antigen DF3,CA 15-3,CA15 3,CA15 3 antigen,CA15.3,Cancer antigen 15-3,Carcinoma associated mucin,Carcinoma-associated mucin,CD 227,CD227,DF3 antigen,EMA,Episialin,H23 antigen,H23AG,KL 6,KL-6,KL6,Krebs von den Lungen-6,MAM 6,MAM6,MCD,MCKD,MCKD1,Medullary cystic kidney disease 1 (autosomal dominant),Medullary cystic kidney disease,autosomal dominant,MUC 1,MUC-1,MUC-1/SEC,MUC-1/X,MUC1,MUC1-alpha,MUC1-beta,MUC1-CT,MUC1-NT,MUC1/ZD,MUC1,Mucin 1,Mucin 1 transmembrane,Mucin 1,cell surface associated,Mucin-1 subunit beta,Peanut reactive urinary mucin,Peanut-reactive urinary mucin,PEM,PEMT,Polymorphic epithelial mucin,PUM,Tumor associated epithelial membrane antigen,Tumor associated epithelial mucin,Tumor associated mucin,Tumor-associated epithelial membrane antigen,Tumor-associated mucin

Background: This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.

Molecular Weight

Observed_MW: 122kDa

Calculated_MW: 10-29kDa/103kDa/121-122kDa

Gene ID 4582
UniProt P15941
Pathways Negative Regulation of intrinsic apoptotic Signaling
Application Notes WB 1:1000 - 1:3000
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C. Avoid freeze / thaw cycles.
Supplier Images
Image no. 1 for anti-Mucin 1, Cell Surface Associated (MUC1) antibody (ABIN6566576) Western blot analysis of extracts of various cell lines, using MUC1 antibody.