CDK6 antibody (Cyclin-Dependent Kinase 6)

Details for Product anti-CDK6 Antibody No. ABIN6566654
Antigen
Reactivity
Human, Mouse (Murine), Rat (Rattus)
247
115
85
5
5
4
4
2
2
2
1
Host
Rabbit
183
64
Clonality
Polyclonal
Conjugate
This CDK6 antibody is un-conjugated
7
4
4
4
4
4
4
4
4
2
2
2
2
2
2
2
2
2
2
Application
Immunohistochemistry (IHC), Western Blotting (WB)
177
100
60
59
42
38
27
16
10
5
2
2
2
1
1
Options
Immunogen A synthetic peptide of human CDK6
Isotype IgG
Purification Affinity purification
Antigen
Alternative Name CDK6 (CDK6 Antibody Abstract)
Background

Synonyms: CDK 6,CDK6,CDK6,Cell division protein kinase 6,Crk 2,Crk2,Cyclin dependent kinase 6,Cyclin-dependent kinase 6,MCPH12,MGC59692,p40,PLSTIRE,Serine/threonine protein kinase PLSTIRE,Serine/threonine-protein kinase PLSTIRE,STQTL11

Background: The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Expression of this gene is up-regulated in some types of cancer. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Molecular Weight

Observed_MW: 37kDa

Calculated_MW: 36kDa

Gene ID 1021
UniProt Q00534
Pathways Cell Division Cycle, Mitotic G1-G1/S Phases
Application Notes WB 1:500 - 1:2000 IHC 1:50 - 1:200
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C. Avoid freeze / thaw cycles.
Supplier Images
Image no. 1 for anti-Cyclin-Dependent Kinase 6 (CDK6) antibody (ABIN6566654) Immunohistochemistry of paraffin-embedded human gastric cancer using CDK6 antibody.
Image no. 2 for anti-Cyclin-Dependent Kinase 6 (CDK6) antibody (ABIN6566654) Western blot analysis of extracts of various cell lines, using CDK6 antibody.
Image no. 3 for anti-Cyclin-Dependent Kinase 6 (CDK6) antibody (ABIN6566654) Immunohistochemistry of paraffin-embedded human brain cancer using CDK6 antibody.