LEF1 antibody (Lymphoid Enhancer-Binding Factor 1)

Details for Product anti-LEF1 Antibody No. ABIN6566691
Antigen
Reactivity
Human, Mouse (Murine)
129
40
29
8
7
6
4
4
4
4
3
3
2
1
1
Host
Rabbit
72
46
7
5
Clonality
Polyclonal
Conjugate
This LEF1 antibody is un-conjugated
5
4
4
3
3
3
1
1
1
1
1
1
Application
Western Blotting (WB)
116
69
24
21
7
7
6
5
3
3
2
1
1
1
Options
Immunogen Recombinant Protein of human LEF1
Isotype IgG
Purification Affinity purification
Antigen
Alternative Name LEF1 (LEF1 Antibody Abstract)
Background

Synonyms: DKFZp586H0919,FLJ46390,LEF 1,LEF-1,Lef1,LEF1,Lymphoid enhancer binding factor 1,Lymphoid enhancer-binding factor 1,T cell specific transcription factor 1 alpha,T cell-specific transcription factor 1-alpha,TCF 1 alpha,TCF1 alpha,TCF1-alpha,TCF10,TCF1alpha,TCF7L3,Transcription factor T cell specific 1 alpha

Background: This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants.

Molecular Weight

Observed_MW: 40kDa

Calculated_MW: 23kDa/31kDa/34kDa/35kDa/41kDa/42kDa/44kDa

Gene ID 51176
UniProt Q9UJU2
Pathways WNT Signaling, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Hormone Metabolic Process, Nuclear Hormone Receptor Binding, Chromatin Binding
Application Notes WB 1:500 - 1:2000
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C. Avoid freeze / thaw cycles.
Supplier Images
Image no. 1 for anti-Lymphoid Enhancer-Binding Factor 1 (LEF1) antibody (ABIN6566691) Western blot analysis of extracts of various cell lines, using LEF1 antibody.