TPMT antibody (Thiopurine S-Methyltransferase)

Details for Product anti-TPMT Antibody No. ABIN6566801
Antigen
Reactivity
Human, Mouse (Murine)
96
20
18
3
2
Host
Rabbit
64
26
6
Clonality
Polyclonal
Conjugate
This TPMT antibody is un-conjugated
9
7
7
2
2
2
2
2
2
1
1
1
Application
Immunofluorescence (IF), Western Blotting (WB)
74
55
37
13
12
5
2
1
1
1
1
Options
Immunogen Recombinant protein of human TPMT
Isotype IgG
Purification Affinity purification
Antigen
Alternative Name TPMT (TPMT Antibody Abstract)
Background

Synonyms: HGNC:12014,S adenosyl L methionine thiopurine S methyltransferase,Thiopurine methyltransferase,Thiopurine S methyltransferase,Thiopurine S-methyltransferase,TPMT,TPMT

Background: This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X.

Molecular Weight

Observed_MW: 28kDa

Calculated_MW: 28kDa

Gene ID 7172
UniProt P51580
Application Notes WB 1:500 - 1:2000 IF 1:10 - 1:100
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Storage -20 °C
Storage Comment Store at -20°C. Avoid freeze / thaw cycles.
Supplier Images
Image no. 1 for anti-Thiopurine S-Methyltransferase (TPMT) antibody (ABIN6566801) Western blot analysis of extracts of K562 cells, using TPMT antibody.
Image no. 2 for anti-Thiopurine S-Methyltransferase (TPMT) antibody (ABIN6566801) Immunofluorescence analysis of U2OS cells using TPMT antibody.