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TPMT Products

(Thiopurine S-Methyltransferase (TPMT))
This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals. A pseudogene for this locus is located on chromosome 18q. [provided by RefSeq, Jul 2008].

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Featured TPMT Categories

TPMT Antibodies

High quality antibodies with extensive validation data.

TPMT ELISA Kits

Reliable ELISA kits for a wide range of species.

TPMT Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended TPMT Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application IF, IHC (p), ELISA, WB
Validations
  • (2)
  • (5)
Cat. No. ABIN563239
Quantity 100 μg
Datasheet Datasheet
Reactivity Dog, Human
Application FACS, IHC, IHC (p), WB
Validations
  • (6)
Cat. No. ABIN1501480
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC, IP, WB
Validations
  • (3)
Cat. No. ABIN7171992
Quantity 100 μg
Datasheet Datasheet

Recommended TPMT ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6970609
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6962695
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6959901
Quantity 96 tests
Datasheet Datasheet

Recommended TPMT Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3074765
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3131858
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1323441
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our TPMT products

Hayashi, Naoi, Nakagawa, Nishikawa, Fukuda, Imajoh-Ohmi, Kondo, Kubo, Yabuki, Hattori, Hirouchi, Sugiyama: "Sorting nexin 27 interacts with multidrug resistance-associated protein 4 (MRP4) and mediates internalization of MRP4." in: The Journal of biological chemistry, Vol. 287, Issue 18, pp. 15054-65, (2012) (PubMed).

Milek, Karas Kuzelicki, Smid, Mlinaric-Rascan: "S-adenosylmethionine regulates thiopurine methyltransferase activity and decreases 6-mercaptopurine cytotoxicity in MOLT lymphoblasts." in: Biochemical pharmacology, Vol. 77, Issue 12, pp. 1845-53, (2009) (PubMed).

Egle, Milek, Mlinaric-Rascan, Fahr, Kristl: "A novel gene delivery system for stable transfection of thiopurine-S-methyltransferase gene in versatile cell types." in: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V, Vol. 69, Issue 1, pp. 23-30, (2008) (PubMed).

Wang, Nguyen, McLaughlin, Sikkink, Ramirez-Alvarado, Weinshilboum: "Human thiopurine S-methyltransferase pharmacogenetics: variant allozyme misfolding and aggresome formation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 26, pp. 9394-9, (2005) (PubMed).

Martin, Trouche, Hagemeier, Sørensen, La Thangue, Kouzarides: "Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein." in: Nature, Vol. 375, Issue 6533, pp. 691-4, (1995) (PubMed).

Synonyms and alternative names related to TPMT

thiopurine S-methyltransferase L homeolog (tpmt.L), thiopurine S-methyltransferase, tandem duplicate 2 (tpmt.2), thiopurine S-methyltransferase TpmT (tpmT), thiopurine S-methyltransferase (MCA0794), thiopurine S-methyltransferase (Pnap_4948), thiopurine S-methyltransferase (Hhal_1383), thiopurine S-methyltransferase (TK90_1044), thiopurine S-methyltransferase (Slit_1144), thiopurine S-methyltransferase (Tint_0842), Thiopurine S-methyltransferase (Fbal_3334), thiopurine S-methyltransferase (Celly_3188), thiopurine S-methyltransferase (Weevi_1737), Thiopurine S-methyltransferase (Psefu_2696), Thiopurine S-methyltransferase (Metme_3860), thiopurine methyltransferase (Tpmt), thiopurine S-methyltransferase (TPMT), thiopurine S-methyltransferase (Tpmt), AW106912, MGC84277, NHLRC1

Protein level used designations for TPMT

  • thiopurine S-methyltransferase
  • Thiopurine S-methyltransferase
  • S-adenosyl-L-methionine:thiopurine S-methyltransferase
  • thiopurine methyltransferase
  • NHL repeat containing 1
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