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TPMT antibody (AA 1-245)

TPMT Reactivity: Human IF, WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN3021279
$589.88
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  • Target See all TPMT Antibodies
    TPMT (Thiopurine S-Methyltransferase (TPMT))
    Binding Specificity
    • 7
    • 5
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-245
    Reactivity
    • 46
    • 12
    • 11
    • 2
    • 2
    Human
    Host
    • 30
    • 10
    • 6
    Rabbit
    Clonality
    • 36
    • 10
    Polyclonal
    Conjugate
    • 23
    • 5
    • 5
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This TPMT antibody is un-conjugated
    Application
    • 29
    • 24
    • 15
    • 5
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Immunofluorescence (IF), Western Blotting (WB)
    Sequence
    MDGTRTSLDI EEYSDTEVQK NQVLTLEEWQ DKWVNGKTAF HQEQGHQLLK KHLDTFLKGK SGLRVFFPLC GKAVEMKWFA DRGHSVVGVE ISELGIQEFF TEQNLSYSEE PITEIPGTKV FKSSSGNISL YCCSIFDLPR TNIGKFDMIW DRGALVAINP GDRKCYADTM FSLLGKKFQY LLCVLSYDPT KHPGPPFYVP HAEIERLFGK ICNIRCLEKV DAFEERHKSW GIDCLFEKLY LLTEK
    Cross-Reactivity
    Human
    Characteristics
    Polyclonal Antibodies
    Immunogen
    Recombinant fusion protein containing a sequence corresponding to amino acids 1-245 of human TPMT (NP_000358.1).
    Isotype
    IgG
  • Application Notes
    WB,1:500 - 1:2000,IF,1:10 - 1:100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid freeze / thaw cycles
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    TPMT (Thiopurine S-Methyltransferase (TPMT))
    Alternative Name
    TPMT (TPMT Products)
    Synonyms
    MGC84277, AW106912, NHLRC1, thiopurine S-methyltransferase L homeolog, thiopurine S-methyltransferase, tandem duplicate 2, thiopurine S-methyltransferase TpmT, thiopurine S-methyltransferase, Thiopurine S-methyltransferase, thiopurine methyltransferase, tpmt.L, tpmt.2, tpmT, MCA0794, Pnap_4948, Hhal_1383, TK90_1044, Slit_1144, Tint_0842, Fbal_3334, Celly_3188, Weevi_1737, Psefu_2696, Metme_3860, Tpmt, TPMT
    Background
    This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X.,TPMT,TPMTD,Signal Transduction,Endocrine & Metabolism,Drug metabolism,TPMT
    Molecular Weight
    28 kDa
    Gene ID
    7172
    UniProt
    P51580
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