PDX1 antibody (Pancreatic and Duodenal Homeobox 1)

Details for Product anti-PDX1 Antibody No. ABIN6566802
Antigen
Reactivity
Human, Mouse (Murine), Rat (Rattus)
243
80
68
7
6
6
5
4
4
3
2
2
2
2
1
1
1
Host
Rabbit
222
29
4
Clonality
Polyclonal
Conjugate
This PDX1 antibody is un-conjugated
17
11
11
10
10
10
7
7
7
7
7
7
1
1
1
1
1
Application
Western Blotting (WB)
162
123
78
35
25
16
16
13
6
4
4
3
3
1
1
Options
Immunogen A synthetic peptide of human PDX1
Isotype IgG
Purification Affinity purification
Antigen
Alternative Name PDX1 (PDX1 Antibody Abstract)
Background

Synonyms: Glucose sensitive factor,Glucose-sensitive factor,GSF,IDX 1,IDX-1,IDX1,Insulin promoter factor 1,Insulin promoter factor 1 homeodomain transcription factor,Insulin upstream factor 1,IPF 1,IPF-1,IPF1,Islet/duodenum homeobox 1,Islet/duodenum homeobox-1,IUF 1,IUF-1,IUF1,MODY4,Pancreas/duodenum homeobox 1,Pancreas/duodenum homeobox protein 1,pancreatic and duodenal homeobox P,PDX 1,PDX-1,PDX1,PDX1,Somatostatin transactivating factor 1,Somatostatin-transactivating factor 1,STF 1,STF-1,STF1

Background: The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4).

Molecular Weight

Observed_MW: 39kDa

Calculated_MW: 30kDa

Gene ID 3651
UniProt P52945
Pathways Nuclear Receptor Transcription Pathway, Positive Regulation of Peptide Hormone Secretion, Steroid Hormone Mediated Signaling Pathway, Hormone Transport, Carbohydrate Homeostasis, Chromatin Binding, Maintenance of Protein Location
Application Notes WB 1:500 - 1:1000
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C. Avoid freeze / thaw cycles.
Supplier Images
Image no. 1 for anti-Pancreatic and Duodenal Homeobox 1 (PDX1) antibody (ABIN6566802) Western blot analysis of extracts of various cell lines, using PDX1 antibody.