KIF14 antibody

Catalog No. ABIN6566849

This anti-KIF14 antibody is a Rabbit Polyclonal antibody detecting KIF14 in IHC and IF. Suitable for Human, Mouse and Rat.

Quick Overview for KIF14 antibody (ABIN6566849)

Target: KIF14 (Kinesin Family Member 14 (KIF14))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KIF14 antibody is un-conjugated

Application: Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-KIF14 Antibody

Purification: Affinity purification

Immunogen: Recombinant fusion protein of human KIF14 (NP_055690.1).

Isotype: IgG

Application Details

Application Notes: IHC 1:50-1:200 IF 1:50-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for KIF14

Target: KIF14 (Kinesin Family Member 14 (KIF14))

Alternative Name: KIF14

Background: This gene encodes a member of the kinesin-3 superfamily of microtubule motor proteins. These proteins are involved in numerous processes including vesicle transport, chromosome segregation, mitotic spindle formation, and cytokinesis. In human HeLa-S3 and 293T cells, this protein is localized to the cytoplasm during interphase, to the spindle poles and spindle microtubules during mitosis, and to the midbody during cytokinesis. An internal motor domain displays microtubule-dependent ATPase activity, consistent with its function as a microtubule motor protein. Knockdown of this gene results in failed cytokinesis with endoreplication, which results in multinucleated cells. This gene has been identified as a likely oncogene in breast, lung and ovarian cancers, as well as retinoblastomas and gliomas. Alternative splicing results in multiple transcript variants.

Molecular Weight:

Observed_MW: 190kDa

Calculated_MW: 186kDa

Gene ID: 9928

UniProt: Q15058