NCOA2 antibody (Nuclear Receptor Coactivator 2)

Details for Product anti-NCOA2 Antibody No. ABIN6566851
Antigen
Reactivity
Human, Mouse (Murine), Rat (Rattus)
69
30
26
5
5
4
4
4
4
2
2
1
1
Host
Rabbit
57
11
1
Clonality
Polyclonal
Conjugate
This NCOA2 antibody is un-conjugated
4
3
3
3
3
3
3
2
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
40
17
14
13
7
5
2
2
2
2
1
1
Options
Immunogen Recombinant protein of human NCOA2
Isotype IgG
Purification Affinity purification
Antigen
Alternative Name NCOA2 (NCOA2 Antibody Abstract)
Background

Synonyms: bHLHe75,Class E basic helix-loop-helix protein 75,glucocorticoid receptor interacting protein 1,GRIP 1,GRIP1,hTIF2,MED1,MGC138808,NCoA 2,NCoA-2,Ncoa2,NCOA2,Nuclear receptor coactivator 2,Oncogene FGR,p160,SRC 2,src2,Steroid receptor coactivator 2,TIF 2,TIF2,Transcriptional intermediary factor 2

Background: The protein encoded by this gene functions as a transcriptional coactivator for nuclear hormone receptors, including steroid, thyroid, retinoid, and vitamin D receptors. The encoded protein acts as an intermediary factor for the ligand-dependent activity of these nuclear receptors, which regulate their target genes upon binding of cognate response elements. This gene has been found to be involved in translocations that result in fusions with other genes in various cancers, including the lysine acetyltransferase 6A (KAT6A) gene in acute myeloid leukemia, the ETS variant 6 (ETV6) gene in acute lymphoblastic leukemia, and the hes related family bHLH transcription factor with YRPW motif 1 (HEY1) gene in mesenchymal chondrosarcoma. Alternative splicing results in multiple transcript variants.

Molecular Weight

Observed_MW: 180kDa

Calculated_MW: 159kDa

Gene ID 10499
UniProt Q15596
Pathways Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, Regulation of Lipid Metabolism by PPARalpha, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, CXCR4-mediated Signaling Events, Thromboxane A2 Receptor Signaling
Application Notes WB 1:500 - 1:2000 IHC 1:50 - 1:200
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C. Avoid freeze / thaw cycles.
Supplier Images
Image no. 1 for anti-Nuclear Receptor Coactivator 2 (NCOA2) antibody (ABIN6566851) Immunohistochemistry of paraffin-embedded rat brain using NCOA2 antibody.
Image no. 2 for anti-Nuclear Receptor Coactivator 2 (NCOA2) antibody (ABIN6566851) Western blot analysis of extracts of various cell lines, using NCOA2 antibody.