Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

GCLC antibody

GCLC Reactivity: Human, Mouse, Rat WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6566902
  • Target See all GCLC Antibodies
    GCLC (Glutamate-Cysteine Ligase, Catalytic Subunit (GCLC))
    Reactivity
    • 59
    • 21
    • 20
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 59
    • 4
    Rabbit
    Clonality
    • 51
    • 12
    Polyclonal
    Conjugate
    • 37
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This GCLC antibody is un-conjugated
    Application
    • 45
    • 26
    • 22
    • 13
    • 10
    • 9
    • 9
    • 5
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Purification
    Affinity purification
    Immunogen
    Recombinant protein of human GCLC
    Isotype
    IgG
    Top Product
    Discover our top product GCLC Primary Antibody
  • Application Notes
    WB 1:500 - 1:2000
    Restrictions
    For Research Use only
  • Concentration
    1 mg/mL
    Buffer
    Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    GCLC (Glutamate-Cysteine Ligase, Catalytic Subunit (GCLC))
    Alternative Name
    GCLC (GCLC Products)
    Background

    Synonyms: EC 6.3.2.2,Gamma ECS,Gamma glutamylcysteine synthetase,Gamma-ECS,Gamma-glutamylcysteine synthetase,GCL,Gclc,GCS,GCS heavy chain,GLCL,GLCLC,Glutamate cysteine ligase catalytic subunit,Glutamate--cysteine ligase catalytic subunit,GSH1

    Background: Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.

    Molecular Weight

    Observed_MW: 72kDa

    Calculated_MW: 72kDa

    Gene ID
    2729
    UniProt
    P48506
    Pathways
    Cell RedoxHomeostasis
You are here:
Support