Synonyms: AV002070,Dickkopf receptor,KREM1,KREMEN,Kremen protein 1,Kremen protein 1 precursor,Kremen1,Kringle coding gene marking the eye and the nose,Kringle containing protein marking the eye and the nose,Kringle containing transmembrane protein 1,Kringle containing transmembrane protein,Kringle domain containing transmembrane protein 1,Kringle domain-containing transmembrane protein 1,Kringle-containing protein marking the eye and the nose,KRM1,RP23 293J16.1
Background: This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein is a component of a membrane complex that modulates canonical WNT signaling through lipoprotein receptor-related protein 6 (LRP6). It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene.