Synonyms: CR,CRGF,Cripto 1,Cripto 1 growth factor,cripto,Cripto-1 growth factor,Cripto1 growth factor,Epidermal growth factor like cripto protein CR1,Epidermal growth factor-like cripto protein CR1,TDGF 1,TDGF1,TDGF1,Teratocarcinoma derived growth factor 1,Teratocarcinoma-derived growth factor 1
Background: This gene encodes an epidermal growth factor-related protein that contains a cripto, FRL-1, and cryptic domain. The encoded protein is an extracellular, membrane-bound signaling protein that plays an essential role in embryonic development and tumor growth. Mutations in this gene are associated with forebrain defects. Pseudogenes of this gene are found on chromosomes 2, 3, 6, 8, 19 and X. Alternate splicing results in multiple transcript variants.