MSH2 antibody

Details for Product No. ABIN6567090
Antigen
Reactivity
Human, Mouse (Murine), Rat (Rattus)
158
59
37
8
7
6
5
4
3
3
3
2
1
1
1
1
Host
Rabbit
105
51
3
Clonality
Polyclonal
Conjugate
Un-conjugated
5
4
4
2
2
2
2
2
2
2
2
2
1
1
1
1
1
Application
Immunoprecipitation (IP), Western Blotting (WB)
112
57
54
42
33
27
14
13
13
7
6
4
3
3
1
Options
Immunogen Recombinant protein of human MSH2
Isotype IgG
Purification Affinity purification
Antigen
Background

Synonyms: BAT26,COCA 1,COCA1,DNA mismatch repair protein Msh2,FCC 1,FCC1,hMSH2,HNPCC 1,HNPCC,HNPCC1,LCFS2,MSH 2,Msh2,MSH2,MutS homolog 2,MutS homolog 2 colon cancer nonpolyposis type 1,MutS protein homolog 2

Background: This locus is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Two transcript variants encoding different isoforms have been found for this gene.

Molecular Weight

Observed_MW: 150kDa

Calculated_MW: 97kDa/104kDa

Gene ID 4436
UniProt P43246
Pathways DNA Damage Repair, Production of Molecular Mediator of Immune Response
Application Notes WB 1:500 - 1:2000 IP 1:20 - 1:50
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C. Avoid freeze / thaw cycles.
Supplier Images
Image no. 1 for anti-MSH2 antibody (ABIN6567090) Western blot analysis of extracts of various cell lines, using MSH2 antibody.
Image no. 2 for anti-MSH2 antibody (ABIN6567090) Immunoprecipitation analysis of 150ug extracts of A549 cells using 3ug MSH2 antibody.