PPP1CA antibody

Catalog No. ABIN5963938

This anti-PPP1CA antibody is a Rabbit Polyclonal antibody detecting PPP1CA in WB and IHC. Suitable for Human and Mouse.

Quick Overview for PPP1CA antibody (ABIN5963938)

Target: PPP1CA (Protein Phosphatase 1, Catalytic Subunit, alpha Isoform (PPP1CA))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PPP1CA antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-PPP1CA Antibody

Purification: Affinity purification

Immunogen: Recombinant protein of human PPP1CA

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000 IHC 1:50 - 1:200

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for PPP1CA

Target: PPP1CA (Protein Phosphatase 1, Catalytic Subunit, alpha Isoform (PPP1CA))

Alternative Name: PPP1CA

Background:

Synonyms: Alpha isoform serine threonine protein phosphatase PP1alpha 1 catalytic subunit,Catalytic subunit,EC 3.1.3.16,MGC15877,MGC1674,PP 1A,PP-1A,PP1A,PP1A,PP1alpha,PP2C ALPHA,PP2CA,Ppp1ca,Protein Phosphatase 2C Alpha Isoform,Serine threonine protein phosphatase PP1 alpha catalytic subunit,Serine threonine protein phosphatase PP1 alpha catalytic subunit protein phosphatase 1,Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

Background: The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human and mice suggest that PP1 is an important regulator of cardiac function. Mouse studies also suggest that PP1 functions as a suppressor of learning and memory. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Molecular Weight:

Observed_MW: 38kDa

Calculated_MW: 32kDa/37kDa/38kDa

Gene ID: 5499

UniProt: P62136

Pathways: M Phase, Cellular Glucan Metabolic Process, Regulation of Carbohydrate Metabolic Process, Lipid Metabolism