TBL1XR1 antibody

Catalog No. ABIN6567965

The Rabbit Polyclonal anti-TBL1XR1 antibody has been validated for WB and IF. It is suitable to detect TBL1XR1 in samples from Human and Mouse.

Quick Overview for TBL1XR1 antibody (ABIN6567965)

Target: TBL1XR1 (Transducin (Beta)-Like 1 X-Linked Receptor 1 (TBL1XR1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TBL1XR1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-TBL1XR1 Antibody

Purification: Affinity purification

Immunogen: Recombinant protein of human TBL1XR1

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000 IF 1:50 - 1:200

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for TBL1XR1

Target: TBL1XR1 (Transducin (Beta)-Like 1 X-Linked Receptor 1 (TBL1XR1))

Alternative Name: TBL1XR1

Background:

Synonyms: C21,DC42,F box like/WD repeat containing protein TBL1XR1,F-box-like/WD repeat-containing protein TBL1XR1,FLJ12894,IRA1,Nuclear receptor corepressor/HDAC3 complex subunit,Nuclear receptor corepressor/HDAC3 complex subunit TBLR1,TBL1 related protein 1,TBL1-related protein 1,TBL1R,TBL1XR1,Transducin (beta) like 1 X linked receptor 1,Transducin beta like 1X related protein 1,Transducin beta-like 1X-related protein 1

Background: This gene is a member of the WD40 repeat-containing gene family and shares sequence similarity with transducin (beta)-like 1X-linked (TBL1X). The protein encoded by this gene is thought to be a component of both nuclear receptor corepressor (N-CoR) and histone deacetylase 3 (HDAC 3) complexes, and is required for transcriptional activation by a variety of transcription factors. Mutations in these gene have been associated with some autism spectrum disorders, and one finding suggests that haploinsufficiency of this gene may be a cause of intellectual disability with dysmorphism. Mutations in this gene as well as recurrent translocations involving this gene have also been observed in some tumors.

Molecular Weight:

Observed_MW: 55-70kDa

Calculated_MW: 55kDa

Gene ID: 79718

UniProt: Q9BZK7

Pathways: Regulation of Lipid Metabolism by PPARalpha