Synonyms: AI843960,AOS3,CBF 1,CBF-1,CBF1,csl,IGKJRB,IGKJRB1,J kappa recombination signal binding protein,J kappa-recombination signal-binding protein,KBF2,NY REN 30 antigen,RBP J,RBP J kappa,RBP JK,RBP-J,RBP-J kappa,RBP-JK,Rbpj,RBPJK,RBPSUH,recombination signal binding protein for immunoglobulin kappa J region,Recombining binding protein suppressor of hairless,Renal carcinoma antigen NY-REN-30,SUH,SUH
Background: The protein encoded by this gene is a transcriptional regulator important in the Notch signaling pathway. The encoded protein acts as a repressor when not bound to Notch proteins and an activator when bound to Notch proteins. It is thought to function by recruiting chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins to Notch signaling pathway genes. Several transcript variants encoding different isoforms have been found for this gene, and several pseudogenes of this gene exist on chromosome 9.