RBPJ antibody (AA 243-485)
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- Target See all RBPJ Antibodies
- RBPJ (Recombination Signal Binding Protein For Immunoglobulin kappa J Region (RBPJ))
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Binding Specificity
- AA 243-485
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This RBPJ antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)
- Cross-Reactivity
- Human, Mouse
- Purification
- >95%, Protein G purified
- Immunogen
- Recombinant Human Recombining binding protein suppressor of hairless protein (243-485AA)
- Isotype
- IgG
- Top Product
- Discover our top product RBPJ Primary Antibody
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- Application Notes
- Recommended dilution: WB:1:2000-1:5000, IHC:1:20-1:200, IF:1:50-1:200,
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 - Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Target
- RBPJ (Recombination Signal Binding Protein For Immunoglobulin kappa J Region (RBPJ))
- Alternative Name
- RBPJ (RBPJ Products)
- Synonyms
- AOS3 antibody, CBF1 antibody, IGKJRB antibody, IGKJRB1 antibody, KBF2 antibody, RBP-J antibody, RBPJK antibody, RBPSUH antibody, SUH antibody, csl antibody, AI843960 antibody, Igkjrb antibody, Igkrsbp antibody, RBP-J kappa antibody, RBPjk antibody, Rbpsuh antibody, Su(H) antibody, XSu(H) antibody, xsu(h)1 antibody, Su(H)1 antibody, Su(h)A antibody, ik:tdsubc_1e8 antibody, rbpj antibody, rbpsuh antibody, xx:tdsubc_1e8 antibody, Su(H)2 antibody, su(h)B antibody, recombination signal binding protein for immunoglobulin kappa J region antibody, recombination signal binding protein for immunoglobulin kappa J region S homeolog antibody, recombination signal binding protein for immunoglobulin kappa J region a antibody, recombination signal binding protein for immunoglobulin kappa J region b antibody, RBPJ antibody, Rbpj antibody, rbpj.S antibody, rbpja antibody, rbpjb antibody
- Background
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Background: Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA. Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4 % oxygen) (PubMed:23303788).
Aliases: AI843960 antibody, AOS3 antibody, CBF 1 antibody, CBF-1 antibody, CBF1 antibody, csl antibody, IGKJRB antibody, IGKJRB1 antibody, J kappa recombination signal binding protein antibody, J kappa-recombination signal-binding protein antibody, KBF2 antibody, NY REN 30 antigen antibody, RBP J antibody, RBP J kappa antibody, RBP JK antibody, RBP-J antibody, RBP-J kappa antibody, RBP-JK antibody, Rbpj antibody, RBPJK antibody, RBPSUH antibody, recombination signal binding protein for immunoglobulin kappa J region antibody, Recombining binding protein suppressor of hairless antibody, Renal carcinoma antigen NY-REN-30 antibody, SUH antibody, SUH_HUMAN antibody
- UniProt
- Q06330
- Pathways
- Notch Signaling, Stem Cell Maintenance, Smooth Muscle Cell Migration
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