PDE6B antibody (phosphodiesterase 6B, CGMP-Specific, Rod, beta)

Details for Product anti-PDE6B Antibody No. ABIN6570798
Antigen
Reactivity
Human, Mouse (Murine), Rat (Rattus)
20
11
10
7
4
4
3
3
3
1
1
Host
Rabbit
19
1
Clonality
Polyclonal
Conjugate
This PDE6B antibody is un-conjugated
1
1
Application
Western Blotting (WB)
18
9
8
3
3
3
Options
Immunogen Recombinant protein of human PDE6B
Isotype IgG
Purification Affinity purification
Antigen
Alternative Name PDE6B (PDE6B Antibody Abstract)
Background

Synonyms: 5''-cyclic phosphodiesterase subunit beta,Congenital stationary night blindness 3 autosomal dominant,CSNB 3,CSNB3,CSNBAD2,GMP PDE beta,GMP-PDE beta,PDE 6 beta,PDE 6B,PDE6B,PDE6B,PDEB,Phosphodiesterase 6B,Phosphodiesterase 6B cGMP specific rod beta,Rd 1,Rd1,Rod cGMP phosphodiesterase beta subunit,Rod cGMP specific 3' 5' cyclic phosphodiesterase beta subunit,Rod cGMP-specific 3'',RP40

Background: Photon absorption triggers a signaling cascade in rod photoreceptors that activates cGMP phosphodiesterase (PDE), resulting in the rapid hydrolysis of cGMP, closure of cGMP-gated cation channels, and hyperpolarization of the cell. PDE is a peripheral membrane heterotrimeric enzyme made up of alpha, beta, and gamma subunits. This gene encodes the beta subunit. Mutations in this gene result in retinitis pigmentosa and autosomal dominant congenital stationary night blindness. Multiple transcript variants encoding different isoforms have been found for this gene.

Molecular Weight

Observed_MW: 98kDa

Calculated_MW: 66kDa/98kDa

Gene ID 5158
UniProt P35913
Pathways Regulation of G-Protein Coupled Receptor Protein Signaling, Phototransduction
Application Notes WB 1:500 - 1:2000
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C. Avoid freeze / thaw cycles.
Supplier Images
Image no. 1 for anti-phosphodiesterase 6B, CGMP-Specific, Rod, beta (PDE6B) antibody (ABIN6570798) Western blot analysis of extracts of various cell lines, using PDE6B antibody.