Exportin 2 antibody

Catalog No. ABIN6571992

The Rabbit Polyclonal anti-Exportin 2 antibody has been validated for WB. It is suitable to detect Exportin 2 in samples from Human.

Quick Overview for Exportin 2 antibody (ABIN6571992)

Target: Exportin 2 (CSE1L) (CSE1 Chromosome Segregation 1-Like (CSE1L))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Exportin 2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Exportin 2 Antibody

Purification: Affinity purification

Immunogen: A synthetic peptide of human CSE1L

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Exportin 2

Target: Exportin 2 (CSE1L) (CSE1 Chromosome Segregation 1-Like (CSE1L))

Alternative Name: CSE1L

Background:

Synonyms: CAS,Cellular apoptosis susceptibility protein,Chromosome segregation 1 (yeast homolog) like,Chromosome segregation 1 Like,Chromosome segregation 1 like protein,Chromosome segregation 1-like protein,Chromosome segregation gene CSE1,CSE 1,CSE 1 chromosome segregation 1 like,CSE 1 chromosome segregation 1 like protein,CSE 1L,CSE1,CSE1 chromosome segregation 1 like (yeast),CSE1 chromosome segregation 1 like,CSE1 chromosome segregation 1 like protein,CSE1L,Exp 2,Exp2,Exportin 2,Exportin-2,Exportin2,Importin alpha re exporter,Importin-alpha re-exporter,MGC117283,MGC130036,MGC130037,XPO 2,XPO2,XPO2

Background: Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene.

Molecular Weight:

Observed_MW: 110kDa

Calculated_MW: 22kDa/103kDa/107kDa/110kDa

Gene ID: 1434

UniProt: P55060

Pathways: Protein targeting to Nucleus