CST3 antibody (AA 31-146)

Catalog No. ABIN6654028

The Rabbit Polyclonal anti-CST3 antibody has been validated for WB, ELISA and IHC (p). It is suitable to detect CST3 in samples from Human and Mouse.

Quick Overview for CST3 antibody (AA 31-146) (ABIN6654028)

Target: CST3 (Cystatin C (CST3))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CST3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-CST3 Antibody

Binding Specificity: AA 31-146

Purification: Antigen affinity purified

Immunogen: Human Cystatin C recombinant protein (amino acids K31-A146) was used as the immunogen for the Cystatin C antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Cystatin C antibody should be determined by the researcher.\. Western blot: 0.5-1 μg/mL,Immunohistochemistry (FFPE): 1-2 μg/mL,Direct ELISA: 0.1-0.5 μg/mL (recombinant human protein)

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the Cystatin C antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for CST3

Target: CST3 (Cystatin C (CST3))

Alternative Name: Cystatin C / Cystatin 3

Background: Cystatin C or cystatin 3, a protein encoded by the CST3 gene, is mainly used as a biomarker of kidney function. Recently, it has been studied for its role in predicting new-onset or deteriorating cardiovascular disease. It also seems to play a role in brain disorders involving amyloid, such as Alzheimer's disease. In humans, all cells with a nucleus (cell core containing the DNA) produce cystatin C as a chain of 120 amino acids. It is found in virtually all tissues and body fluids. It is a potent inhibitor of lysosomal proteinases (enzymes from a special subunit of the cell that break down proteins) and probably one of the most important extracellular inhibitors of cysteine proteases (it prevents the breakdown of proteins outside the cell by a specific type of protein degrading enzymes). Cystatin C belongs to the type 2 cystatin gene family.

UniProt: P01034