CCL2 antibody (AA 24-96)

Catalog No. ABIN6654181

The Rabbit Polyclonal anti-CCL2 antibody has been validated for WB and ELISA (Capture). It is suitable to detect CCL2 in samples from Rat.

Quick Overview for CCL2 antibody (AA 24-96) (ABIN6654181)

Target: CCL2 (Chemokine (C-C Motif) Ligand 2 (CCL2))

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CCL2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA (Capture)

Product Details anti-CCL2 Antibody

Binding Specificity: AA 24-96

Purification: Antigen affinity purified

Immunogen: Amino acids Q24-R96 from the rat protein were used as the immunogen for the CCL2 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the CCL2 antibody should be determined by the researcher.\. Western blot: 0.5-1 μg/mL,ELISA (Capture): 1-5 μg/mL (recombinant rat protein)

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the CCL2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for CCL2

Target: CCL2 (Chemokine (C-C Motif) Ligand 2 (CCL2))

Alternative Name: CCL2 / MCP1

Background: Monocyte chemoattractant protein-1 (MCP-1), a member of the chemokine (chemotactic cytokine) family, is a potent monocyte agonist that is upregulated by oxidized lipids. MCP-1 is also known as CCL2, SCYA2, MCAF. MCAF is a member of family of factors involved in immune and inflammatory responses. The amino acid sequence deduced from the nucleotide sequence reveals the primary structure of the MCAF precursor to be composed of a putative signal peptide sequence of 23 amino acid residues and a mature MCAF sequence of 76 amino acid residues. MCP-1 plays a unique and crucial role in the initiation of atherosclerosis and may provide a new therapeutic target in this disorder. Human MCP-1 is a 8.7KDa non-glycoprotein, consisting of 99 amino acids in precursor form and 76 amino acids in mature form.

UniProt: P14844

Pathways: Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, ER-Nucleus Signaling, Unfolded Protein Response, The Global Phosphorylation Landscape of SARS-CoV-2 Infection