GAP43 antibody (pSer41)

Catalog No. ABIN6658158

Supplier Product No.: 612-401-d59

This Rabbit Polyclonal antibody specifically detects GAP43 in WB. It exhibits reactivity toward Rat.

Quick Overview for GAP43 antibody (pSer41) (ABIN6658158)

Target: GAP43 (Growth Associated Protein 43 (GAP43))

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GAP43 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-GAP43 Antibody

Binding Specificity: pSer41

Supplier Product No.: 612-401-d59

Supplier: Rockland

Purpose: Neuromodulin phospho S41 Antibody

Cross-Reactivity (Details): This antibody is specific for the phosphorylated forms of the protein.

Purification: Anti-GAP43 pS41 antibody was affinity purified from monospecific antiserum by immunoaffinity purification.

Immunogen: Anti-Neuromodulin Antibody was produced by repeated immunizations with a synthetic phospho-peptide corresponding to amino acid residues surrounding Ser41 of GAP43.

Isotype: IgG

Application Details

Application Notes:

Western_Blot_Dilution: 1:1000

Other: User Optimized

Comment:

Anti-GAP43 (Rabbit) antibody is tested for use in Western Blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band of approximately 50 kDa in size corresponding to neuromodulin protein phosphorylated at Ser41 in the appropriate cell lysate or extract. In some tissues, the antibody also recognized a higher molecular weight protein that may be an aggregate or oligomer.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer:

Buffer: 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5

Stabilizer: 0.1 mg/mL Bovine Serum Albumin (BSA) - IgG and Protease free, 50 % (v/v) Glycerol

Storage: 4 °C,-20 °C

Storage Comment: Store vial at -20° C prior to opening.  This product is stable at 4° C as an undiluted liquid.  For extended storage, aliquot contents and freeze at -20° C or below.  Avoid cycles of freezing and thawing. Dilute only prior to immediate use.

Expiry Date: 12 months

Target Details for GAP43

Target: GAP43 (Growth Associated Protein 43 (GAP43))

Alternative Name: Neuromodulin (GAP43)

Background:

Synonyms: Neuromodulin, Axonal membrane protein GAP-43, Growth-associated protein 43, Protein F1, Neural phosphoprotein B-50, pp46

Background: Gap-43 pS41 antibody detects phophorylated GAP43 at position S41. Gap43 is thought to have an important role in development and plasticity because it is expressed at high levels in neuronal growth cones during development and during axonal regeneration. There is also evidence from knockout animals that Gap-43 serves to amplify pathfinding signals from the growth cone. Gap-43 is thought to mediate at least some of these effects via interaction with actin. Importantly, phosphorylation at Ser41 by protein kinase C modulates the interaction of Gap-43 with actin and may also affect eurotransmitter release during forms of plasticity like LTP. Anti-Gap-43 pS41 antibody is ideal for investigators involved in Cell Signaling, Neuroscience, and Signal Transduction research.

Gene Name: GAP43

Gene ID: 29423

UniProt: P07936