GABBR1 antibody (pSer923)

Catalog No. ABIN6658230

Supplier Product No.: 612-401-d54

This Rabbit Polyclonal antibody specifically detects GABBR1 in WB. It exhibits reactivity toward Ratand has been mentioned in 1 publication.

Quick Overview for GABBR1 antibody (pSer923) (ABIN6658230)

Target: GABBR1 (gamma-aminobutyric Acid (GABA) B Receptor, 1 (GABBR1))

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GABBR1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-GABBR1 Antibody

Binding Specificity: pSer923

Supplier Product No.: 612-401-d54

Supplier: Rockland

Purpose: GABA(B) Receptor 1 phospho S923 Antibody

Cross-Reactivity (Details): Anti-GABA(B) Receptor 1 pS923 Antibody is directed against rat phosphorylated GABA(B) Receptor .

Purification: The antibody was affinity purified from monospecific antiserum by immunoaffinity purification.

Immunogen: Anti-GABA(B) Receptor 1 pS923 Antibody was produced by repeated immunizations with synthetic phospho-peptide corresponding to amino acid residues surrounding Ser 923 of rat GABA B R1.

Isotype: IgG

Application Details

Application Notes: Optional[Neutralization_Dilution]: 1:1000

Comment:

Anti-GABA(B) Receptor 1 pS923 (Rabbit) antibody is tested for use in Western Blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band of approximately 102 kDa in size corresponding to GABA(B) receptor 1 protein phosphorylated at Ser923 in the appropriate cell lysate or extract.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer:

Buffer: 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5

Stabilizer: 0.1 mg/mL Bovine Serum Albumin (BSA) - IgG and Protease free, 50 % (v/v) Glycerol

Storage: 4 °C,-20 °C

Storage Comment: Store vial at -20° C prior to opening.  This product is stable at 4° C as an undiluted liquid.  For extended storage, aliquot contents and freeze at -20° C or below.  Avoid cycles of freezing and thawing. Dilute only prior to immediate use.

Expiry Date: 12 months

References for anti-GABBR1 antibody (ABIN6658230)

Feng, Gao, Yue, Liu, Zhou, Ren, Teng: "Autophagy-lysosome dysfunction is involved in gastric ischemia-reperfusion injury by promoting microglial activation in the paraventricular nucleus." in: Journal of biochemical and molecular toxicology, Vol. 36, Issue 2, pp. e22957, (2022) (PubMed).

Target Details for GABBR1

Target: GABBR1 (gamma-aminobutyric Acid (GABA) B Receptor, 1 (GABBR1))

Alternative Name: GABA(B) Receptor 1

Background:

Synonyms: Gamma-aminobutyric acid type B receptor subunit 1, GABA-B-R1, GABA-BR1, GABABR1, Gb1

Background: GABA(A) Receptor 1 pS923 Antibody detects phosphorylated GABA(A) Receptor gamma 2. Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. There are two major classes of GABA receptors: the GABAA and the GABAB subtype of receptors. GABAB receptors are heterodimeric G protein-coupled receptors that mediate slow synaptic inhibition in the central nervous system. Phosphorylation enhances GABAB receptor effector coupling. Phosphorylation of Ser 923 is thought to be important in the regulation of GABAB receptor function. GABA(B) Receptor 1 pS923 antibody is ideal for investigators involved in Neuroscience.

Gene Name: GABBR1

Gene ID: 81657, 8393403

UniProt: Q9Z0U4

Pathways: Positive Regulation of Peptide Hormone Secretion, cAMP Metabolic Process