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GABRA5 antibody (Cytoplasmic Loop)

Rockland 612-401-c78 GABRA5 Reactivity: Rat WB Host: Rabbit Polyclonal unconjugated
Rockland
Catalog No. ABIN6658274
Supplier Product No.: 612-401-c78
  • Target See all GABRA5 Antibodies
    GABRA5 (gamma-aminobutyric Acid (GABA) A Receptor, alpha 5 (GABRA5))
    Binding Specificity
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Cytoplasmic Loop
    Reactivity
    • 22
    • 16
    • 15
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Rat
    Host
    • 22
    • 6
    Rabbit
    Clonality
    • 16
    • 12
    Polyclonal
    Conjugate
    • 21
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This GABRA5 antibody is un-conjugated
    Application
    • 20
    • 10
    • 3
    • 3
    • 3
    • 1
    Western Blotting (WB)
    Supplier Product No.
    612-401-c78
    Supplier
    Rockland
    Purpose
    GABA(A) Receptor alpha 5 Antibody
    Cross-Reactivity (Details)
    Anti-GABA(A) Receptor alpha 5 Antibody is directed against rat GABA(A) Receptor alpha 5.
    Purification
    The antibody was affinity purified from monospecific antiserum by immunoaffinity purification.
    Immunogen
    Anti-GABA(A) Receptor alpha 5 Antibody was produced by repeated immunizations with recombinant fusion proteins from the cytoplasmic loop of the alpha 5 subunit of rat GABAA.
    Isotype
    IgG
    Top Product
    Discover our top product GABRA5 Primary Antibody
  • Application Notes
    Optional[Neutralization_Dilution]: 1:1000
    Comment

    Anti-GABA(A) Receptor alpha 5 (Rabbit) antibody is tested for use in Western Blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band of approximately 55 kDa in size corresponding to the alpha 5 subunit of the GABA(A) receptor in Western Blots of rat brain extracts.

    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer

    Buffer: 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5

    Stabilizer: 0.1 mg/mL Bovine Serum Albumin (BSA) - IgG and Protease free, 50 % (v/v) Glycerol

    Storage
    4 °C,-20 °C
    Storage Comment
    Store vial at -20° C prior to opening. This product is stable at 4° C as an undiluted liquid. For extended storage, aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Dilute only prior to immediate use.
    Expiry Date
    12 months
  • Target
    GABRA5 (gamma-aminobutyric Acid (GABA) A Receptor, alpha 5 (GABRA5))
    Alternative Name
    GABA(A) Receptor alpha 5 (GABRA5 Products)
    Background

    Synonyms: Gamma-aminobutyric acid receptor subunit alpha-5, GABA(A) receptor subunit alpha-5, Gabra5

    Background: Anti-GABA(A) Receptor alpha 5 Antibody detects GABA(A) Receptor alpha 4. Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date six alphas, four betas and four gammas, plus alternative splicing variants of some of these subunits, have been identified. Injection in oocytes or mammalian cell lines of cRNA coding for alpha- and beta-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a gamma-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different alpha-subunits of the receptor. GABA(A) receptor alpha 5 antibody is ideal for investigators involved in Neuroscience.

    Gene Name: GABRA5

    Gene ID
    29707
    NCBI Accession
    NP_058991
    UniProt
    P19969
    Pathways
    Sensory Perception of Sound, Synaptic Membrane
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