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SNCA antibody (Atto 488)

SNCA Reactivity: Human, Rat, Mouse WB, ELISA Host: Rabbit Polyclonal Atto 488
Catalog No. ABIN6698735
  • Target See all SNCA Antibodies
    SNCA (Synuclein, alpha (SNCA))
    Reactivity
    • 306
    • 207
    • 207
    • 14
    • 10
    • 10
    • 9
    • 7
    • 7
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Rat, Mouse
    Host
    • 247
    • 101
    • 6
    • 1
    • 1
    • 1
    Rabbit
    Clonality
    • 231
    • 127
    Polyclonal
    Conjugate
    • 157
    • 25
    • 22
    • 17
    • 11
    • 9
    • 9
    • 9
    • 9
    • 9
    • 9
    • 8
    • 8
    • 7
    • 7
    • 7
    • 6
    • 6
    • 6
    • 6
    • 6
    • 5
    This SNCA antibody is conjugated to Atto 488
    Application
    • 249
    • 171
    • 111
    • 82
    • 80
    • 74
    • 68
    • 54
    • 49
    • 49
    • 23
    • 21
    • 13
    • 9
    • 7
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA
    Specificity
    Detects ~14.46kda.
    Purification
    Protein A Purified
    Immunogen
    Synthetic peptide from the full length of Human Alpha Synuclein
    Top Product
    Discover our top product SNCA Primary Antibody
  • Application Notes
    • WB (1:1000)
    • optimal dilutions for assays should be determined by the user.
    Comment

    A 1:1000 dilution of ABIN6698735 was sufficient for detection of Alpha Synuclein in 15 μg of mouse Brain cell lysates by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS pH 7.4, 50 % glycerol, 0.09 % Sodium Azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
  • Target
    SNCA (Synuclein, alpha (SNCA))
    Alternative Name
    Alpha Synuclein (SNCA Products)
    Synonyms
    snca antibody, MGC64356 antibody, LOC619283 antibody, NACP antibody, alphaSYN antibody, PARK1 antibody, PARK4 antibody, PD1 antibody, synuclein alpha L homeolog antibody, alpha-synuclein antibody, synuclein alpha antibody, synuclein, alpha antibody, snca.L antibody, LOC619283 antibody, SNCA antibody, Snca antibody
    Background
    Alpha-Synuclein (SNCA) is expressed predominantly in the brain, where it is concentrated in presynaptic nerve terminals (1). Alpha-synuclein is highly expressed in the mitochondria of the olfactory bulb, hippocampus, striatum and thalamus (2). Functionally, it has been shown to significantly interact with tubulin (3), and may serve as a potential microtubule-associated protein. It has also been found to be essential for normal development of the cognitive functions, inactivation may lead to impaired spatial learning and working memory (4). SNCA fibrillar aggregates represent the major non A-beta component of Alzheimers disease amyloid plaque, and a major component of Lewy body inclusions, and Parkinson's disease. Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive accumulation in selected neurons of protein inclusions containing alpha-synuclein and ubiquitin (5, 6).
    Gene ID
    6622
    NCBI Accession
    NP_000336
    Pathways
    Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Platelet-derived growth Factor Receptor Signaling, Negative Regulation of Transporter Activity, Regulation of long-term Neuronal Synaptic Plasticity
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