SNCA antibody (Synuclein, alpha) (Atto 594)

Details for Product anti-SNCA Antibody No. ABIN6698737
Antigen
  • snca
  • MGC64356
  • LOC619283
  • NACP
  • alphaSYN
  • PARK1
  • PARK4
  • PD1
  • synuclein alpha L homeolog
  • alpha-synuclein
  • synuclein alpha
  • synuclein, alpha
  • snca.L
  • LOC619283
  • SNCA
  • Snca
Reactivity
Human, Mouse (Murine), Rat (Rattus)
816
536
517
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18
16
13
11
10
7
4
3
2
2
1
1
Host
Rabbit
551
265
15
13
2
2
Clonality
Polyclonal
Conjugate
This SNCA antibody is conjugated to Atto 594
43
29
27
16
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16
16
13
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12
11
11
11
11
11
11
11
11
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10
7
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6
2
1
Application
ELISA, Western Blotting (WB)
645
454
299
208
172
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84
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25
19
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16
7
2
2
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1
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Options
Immunogen Synthetic peptide from the full length of Human Alpha Synuclein
Specificity Detects ~14.46kda.
Purification Protein A Purified
Plasmids, Primers & others Plasmids, Primers & others SNCA products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name Alpha Synuclein (SNCA Antibody Abstract)
Background Alpha-Synuclein (SNCA) is expressed predominantly in the brain, where it is concentrated in presynaptic nerve terminals (1). Alpha-synuclein is highly expressed in the mitochondria of the olfactory bulb, hippocampus, striatum and thalamus (2). Functionally, it has been shown to significantly interact with tubulin (3), and may serve as a potential microtubule-associated protein. It has also been found to be essential for normal development of the cognitive functions, inactivation may lead to impaired spatial learning and working memory (4). SNCA fibrillar aggregates represent the major non A-beta component of Alzheimers disease amyloid plaque, and a major component of Lewy body inclusions, and Parkinson's disease. Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive accumulation in selected neurons of protein inclusions containing alpha-synuclein and ubiquitin (5, 6).
Gene ID 6622
NCBI Accession NP_000336
Pathways Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Platelet-derived growth Factor Receptor Signaling, Negative Regulation of Transporter Activity, Regulation of long-term Neuronal Synaptic Plasticity
Application Notes
  • WB (1:1000)
  • optimal dilutions for assays should be determined by the user.
Comment

A 1:1000 dilution of ABIN6698737 was sufficient for detection of Alpha Synuclein in 15 μg of mouse Brain cell lysates by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.

Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer PBS pH 7.4, 50 % glycerol, 0.09 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage -20 °C
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