CNR1 antibody (AA 1-75) (DyLight 550)

Catalog No. ABIN7354602

The Rabbit Polyclonal anti-CNR1 antibody has been validated for FACS. It is suitable to detect CNR1 in samples from Human.

Quick Overview for CNR1 antibody (AA 1-75) (DyLight 550) (ABIN7354602)

Target: CNR1 (Cannabinoid Receptor 1 (CNR1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CNR1 antibody is conjugated to DyLight 550

Application: Flow Cytometry (FACS)

Product Details anti-CNR1 Antibody (DyLight 550)

Binding Specificity: AA 1-75

Purpose: Anti-Human Cannabinoid Receptor I DyLight® 550 conjugated CNR1 Antibody

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-Human Cannabinoid Receptor I DyLight® 550 conjugated CNR1 Antibody -Dyl550. Tested in Flow Cytometry applications. This antibody reacts with Human.

Purification: Immunogen affinity purified.

Immunogen: E. coli-derived human Cannabinoid Receptor I recombinant protein (Position: M1-Q75).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells1. "Entrez Gene: CNR1 cannabinoid receptor 1 (brain)". 2. Russo, P., Strazzullo, P., Cappuccio, F. P., Tregouet, D. A., Lauria, F., Loguercio, M., Barba, G., Versiero, M., Siani, A. Genetic variations at the endocannabinoid type 1 receptor gene (CNR1) are associated with obesity phenotypes in men. J. Clin. Endocr. Metab. 92: 2382-2386, 2007.

Comment:

Other applications have not been tested. Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Target Details for CNR1

Target: CNR1 (Cannabinoid Receptor 1 (CNR1))

Alternative Name: CNR1

Background:

Synonyms: Cannabinoid receptor 1, CB-R, CB1, CANN6, CNR1, CNR

Tissue Specificity: Widely expressed, with highest levels in fetal and adult brain. Expression levels of isoform 2 and isoform 3 are much lower than those of isoform 1.

Background: The cannabinoid receptor type 1, often abbreviated as CB1, is a G protein-coupled cannabinoid receptor located primarily in the central and peripheral nervous system. This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene.

Molecular Weight: 39 kDa

Gene ID: 1268

UniProt: P21554

Pathways: Feeding Behaviour