CD81 antibody (AA 113-201) (DyLight 550)

Catalog No. ABIN7354597

The Rabbit Polyclonal anti-CD81 antibody has been validated for FACS. It is suitable to detect CD81 in samples from Human.

Quick Overview for CD81 antibody (AA 113-201) (DyLight 550) (ABIN7354597)

Target: CD81

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CD81 antibody is conjugated to DyLight 550

Application: Flow Cytometry (FACS)

Product Details anti-CD81 Antibody (DyLight 550)

Binding Specificity: AA 113-201

Purpose: Anti-Human TAPA1 DyLight® 550 conjugated CD81 Antibody

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-Human TAPA1 DyLight® 550 conjugated CD81 Antibody -Dyl550. Tested in Flow Cytometry applications. This antibody reacts with Human.

Purification: Immunogen affinity purified.

Immunogen: E. coli-derived human TAPA1 recombinant protein (Position: F113-K201).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells1. Andria ML, Hsieh CL, Oren R, Francke U, Levy S (August 1991)."Genomic organization and chromosomal localization of the TAPA-1 gene".Journal of Immunology. 147 (3): 1030-6. 2. Levy S, Todd SC, Maecker HT (1998). "CD81 (TAPA-1): a molecule involved in signal transduction and cell adhesion in the immune system.".Annu Rev Immunol. 16: 89-109.

Comment:

Other applications have not been tested. Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Target Details for CD81

Target: CD81

Alternative Name: CD81

Background:

Synonyms: CD81 antigen, 26 kDa cell surface protein TAPA-1, Target of the antiproliferative antibody 1, Tetraspanin-28, Tspan-28, CD81, CD81, TAPA1, TSPAN28

Tissue Specificity: Hematolymphoid, neuroectodermal and mesenchymal tumor cell lines.

Background: CD81 Molecule, also known as CD81 (Cluster of Differentiation 81), is a protein which in humans is encoded by the CD81 gene. The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This protein appears to promote muscle cell fusion and support myotube maintenance. Also it may be involved in signal transduction. This gene is localized in the tumor-suppressor gene region and thus it is a candidate gene for malignancies. Two transcript variants encoding different isoforms have been found for this gene.

Molecular Weight: 39 kDa

Gene ID: 975

UniProt: P60033

Pathways: Inositol Metabolic Process, Hepatitis C