RXFP2 antibody

Catalog No. ABIN6719634

This anti-RXFP2 antibody is a Rabbit Polyclonal antibody detecting RXFP2 in WB and FACS. Suitable for Human.

Quick Overview for RXFP2 antibody (ABIN6719634)

Target: RXFP2 (Relaxin/insulin-Like Family Peptide Receptor 2 (RXFP2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RXFP2 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS)

Product Details anti-RXFP2 Antibody

Purpose: Anti-GPCR LGR8/RXFP2 Antibody Picoband®

Sequence: MIVFLVFKHL FSLRLITMFF LLHFIVLINV KDFALTQ

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-GPCR LGR8/RXFP2 Antibody Picoband® (ABIN6719634). Tested in Flow Cytometry, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human GPCR LGR8.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.1-0.5 μg/mL
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells
1. Ars, E., Lo Giacco, D., Bassas, L., Nuti, F., Rajmil, O., Ruiz, P., Garat, J. M., Ruiz-Castane, E., Krausz, C. Further insights into the role of T222P variant of RXFP2 in non-syndromic cryptorchidism in two Mediterranean populations. Int. J. Androl. 34: 333-338, 2010. 2. Ferlin, A., Simonato, M., Bartoloni, L., Rizzo, G., Bettella, A., Dottorini, T., Dallapiccola, B., Foresta, C. The INSL3-LGR8/GREAT ligand-receptor pair in human cryptorchidism. J. Clin. Endocr. Metab. 88: 4273-4279, 2003. 3. Harris, R. M., Finlayson, C., Weiss, J., Fisher, L., Hurley, L., Barrett, T., Emge, D., Bathgate, R. A. D., Agoulnik, A. I., Jameson, J. L. A missense mutation in LRR8 of RXFP2 is associated with cryptorchidism. Mammalian Genome 21: 442-449, 2010.

Comment:

Tested Species: In-house tested species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na₂HPO₄, 0.05 mg NaN₃.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Target Details for RXFP2

Target: RXFP2 (Relaxin/insulin-Like Family Peptide Receptor 2 (RXFP2))

Alternative Name: RXFP2

Background:

Synonyms: Relaxin receptor 2, G-protein coupled receptor 106, G-protein coupled receptor affecting testicular descent, Leucine-rich repeat-containing G-protein coupled receptor 8, Relaxin family peptide receptor 2, RXFP2, GPR106, GREAT, LGR8

Tissue Specificity: Expressed mainly in the brain, kidney, muscle, testis, thyroid, uterus, peripheral blood cells and bone marrow.

Background: Relaxin/insulin-like family peptide receptor 2, also known as RXFP2, is a human G-protein coupled receptor. It is mapped to 13q13.1. This gene encodes a member of the GPCR (G protein-coupled, 7-transmembrane receptor) family. Mutations in this gene are associated with cryptorchidism. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Molecular Weight: 86 kDa

Pathways: cAMP Metabolic Process, Myometrial Relaxation and Contraction