Fc gamma RII (CD32) antibody (Alexa Fluor 488)

Catalog No. ABIN6722611

This Mouse Monoclonal antibody specifically detects in FACS. It exhibits reactivity toward Human.

Quick Overview for Fc gamma RII (CD32) antibody (Alexa Fluor 488) (ABIN6722611)

Target: Fc gamma RII (CD32)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: Alexa Fluor 488

Application: Flow Cytometry (FACS)

Clone: IV-3

Product Details

Isotype: IgG2b kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.05 % Proclin300, 1 % BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.

Target Details

Target: Fc gamma RII (CD32)

Alternative Name: CD32

Background:

Synonyms: Low affinity immunoglobulin gamma Fc region receptor II-b,FCGR2B,IgG Fc receptor II-b,CDw32,Fc-gamma RII-b,Fc-gamma-RIIb,FcRII-b,CD32,FCG2, IGFR2

Background: CD32 is a 40 kD polymorphic transmembrane glycoprotein also known as FcγRII and FCRII. It is an immunoglobulin superfamily member expressed on monocytes/macrophages, granulocytes, platelets and B cells. There are at least 6 isoforms of CD32 resulting from alternative mRNA splicing. CD32 mediates phagocytosis and oxidative burst in granulocytes, as well as platelet aggregation and immunomodulation. The extracellular domain of CD32 binds to polymeric and aggregated IgG and immune complexes, while the intracellular domain has been reported to associate with SHP-1 (B1 isoform).

Gene ID: 2212

UniProt: P31994