PD-L1 antibody
Quick Overview for PD-L1 antibody (ABIN6727404)
Target
See all PD-L1 AntibodiesReactivity
Host
Clonality
Conjugate
Application
Clone
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Purification
- Purified
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Isotype
- IgG2b, kappa
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Comment
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Matching Isotype Control: Purified Rat IgG2b, κ Isotype Control (ABIN7469856)
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Restrictions
- For Research Use only
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Concentration
- 0.5 mg/mL
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Buffer
- PBS with 0.05 % Proclin300
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Preservative
- ProClin
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Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Storage
- 4 °C
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Storage Comment
- Store at 2~8°C. Do not freeze.
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- PD-L1 (CD274 (PD-L1))
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Alternative Name
- CD274/PD-L1
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Background
- B7-H1, PD-L1,Programmed cell death ligand 1,B7 homolog 1,B7-H, B7H1, PDL1, PDCD1L1, PDCD1LG1,CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. It is expressed on T cells, B cells, NK cells, dendritic cells, IFN-γ activated endothelial cells, and monocytes. B7-H1 is one of the ligands of PD-1. The interaction of B7-H1 with PD-1 plays an important role in the inhibition of T cell responses. Other studies have shown that B7-H1 is able to costimulate T cell growth and cytokine production. CD274 is involved in costimulation essential for T cell proliferation and production of IL-10 and IFN-γ, in an IL-2-dependent and a PD-1-independent manner. Its interaction with PD-1 inhibits T cell proliferation and cytokine production.
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Gene ID
- 60533
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UniProt
- Q9EP73
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Pathways
- Cancer Immune Checkpoints
Target
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