CD3 antibody (iFluor™700)

Catalog No. ABIN6731068

This Mouse Monoclonal antibody specifically detects CD3 in FACS. It exhibits reactivity toward Human.

Quick Overview for CD3 antibody (iFluor™700) (ABIN6731068)

Target: CD3

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD3 antibody is conjugated to iFluor™700

Application: Flow Cytometry (FACS)

Grade: GMP Grade

Clone: OKT3

Product Details anti-CD3 Antibody (iFluor™700)

Purpose: CD3 iFluor™ 700 Antibody

Characteristics: CD3ε is a 20kD peptide chain, which together with CD3λ, CD3δ, and CD3ζ, and a T cell receptor (α/β or γ/) form the CD3/T-cell receptor complex. It is a specific marker for T lymphocytes, NK T cells, and some thymocytes. Crosslinking of TCR initiates an intracellular signaling cascade resulting in cellular activation and proliferation. The OKT3 antibody shows potent immunosuppressive properties in vivo and has been proved effective in the treatment of renal, heart, and liver allograft rejection.

Purification: Purified

Purity: >95 %

Immunogen: Human peripheral blood lymphocytes

Isotype: IgG2a, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS pH 7.2, 0.2 % (w/v) BSA, 0.09 % (w/v) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: 2-8°C, Conjugated antibodies should never be frozen.

Target Details for CD3

Target: CD3

Alternative Name: CD3

Gene ID: 916

NCBI Accession: NM_000733

UniProt: P07766

Pathways: TCR Signaling, Ubiquitin Proteasome Pathway