CYLD antibody (N-Term)

Catalog No. ABIN6756791

This anti-CYLD antibody is a Rabbit Polyclonal antibody detecting CYLD in WB. Suitable for Human and Mouse.

Quick Overview for CYLD antibody (N-Term) (ABIN6756791)

Target: CYLD (Cylindromatosis (Turban Tumor Syndrome) (CYLD))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CYLD antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CYLD Antibody

Binding Specificity: N-Term

Specificity: Human CYLD

Purification: Protein A purified

Immunogen: A recombinant protein fragment from the N-terminal region of human CYLD.

Type of Immunogen: Recombinant protein

Isotype: IgG

Application Details

Application Notes: Approved: WB (2 - 5 μg/mL)

Usage: CYLD is involved in multiple physiological processes including immune response, osteoclastogenesis and spermatogenesis. It is a tumor suppressor via its negative regulation of NF-kB activation. CYLD is a deubiquitinase, removing ubiquitin chains from tumor-necrosis factor receptor-associated factor 2 (TRAF2) and thereby preventing its activation of IkB, a regulator of NF-kB. NF-kB remains sequestered in the cytoplasm, unable to translocate to the nucleus and initiate cell survival and oncogenetic signaling.

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: PBS,  pH 7.4, 0.1 mg/mL BSA, 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: avoid freeze thaw cycles

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze-thaw cycles.

Target Details for CYLD

Target: CYLD (Cylindromatosis (Turban Tumor Syndrome) (CYLD))

Alternative Name: CYLD

Background: Name/Gene ID: CYLD

Synonyms: CYLD, CDMT, Deubiquitinating enzyme CYLD, CYLDI, EAC, HSPC057, MFT1, MFT, SBS, TEM, BRSS, Ubiquitin thiolesterase CYLD, USPL2, CYLD1, KIAA0849, Ubiquitin thioesterase CYLD

Gene ID: 1540

Pathways: Apoptosis, Activation of Innate immune Response