GRM2/4 antibody (AA 31-130) (Biotin)
Quick Overview for GRM2/4 antibody (AA 31-130) (Biotin) (ABIN677920)
Target
Reactivity
Host
Clonality
Conjugate
Application
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Binding Specificity
- AA 31-130
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Predicted Reactivity
- Human,Mouse,Rat
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Purification
- Purified by Protein A.
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Immunogen
- KLH conjugated synthetic peptide derived from human GRM2+GRM4
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Isotype
- IgG
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Application Notes
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WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500 -
Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- 1 μg/μL
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Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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Preservative
- ProClin
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Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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Storage
- -20 °C
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Storage Comment
- Store at -20°C for 12 months.
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Expiry Date
- 12 months
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- GRM2/4 (Glutamate Receptor, Metabotropic 2/4 (GRM2/4))
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Alternative Name
- GRM2+GRM4
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Background
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Synonyms: NULL
Background: L glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.
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Gene ID
- 2912
Target
-
