BMP4 antibody (AA 280-330) (Cy7)

Catalog No. ABIN685648

This Rabbit Polyclonal antibody specifically detects BMP4 in WB. It exhibits reactivity toward Rat and Mouse.

Quick Overview for BMP4 antibody (AA 280-330) (Cy7) (ABIN685648)

Target: BMP4 (Bone Morphogenetic Protein 4 (BMP4))

Reactivity: Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BMP4 antibody is conjugated to Cy7

Application: Western Blotting (WB)

Product Details anti-BMP4 Antibody (Cy7)

Binding Specificity: AA 280-330

Cross-Reactivity: Mouse, Sheep

Predicted Reactivity: Human,Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from rat BMP4

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for BMP4

Target: BMP4 (Bone Morphogenetic Protein 4 (BMP4))

Alternative Name: Bmp4

Background:

Synonyms: BMP 4, BMP2B, BMP2B1, Bone morphogenetic protein 4, DVR4, ZYME, BMP4_HUMAN, BMP-4, Bone morphogenetic protein 2B, BMP-2B.

Background: BMPs (bone morphogenetic proteins) belong to the TGF beta superfamily of structurally related signaling proteins. Members of this superfamily are widely represented throughout the animal kingdom and have been implicated in a variety of developmental processes. Proteins of the TGF beta superfamily are disulfide-linked dimers composed of two 12-15 kDa polypeptide chains. As implied by their name, BMPs initiate, promote and regulate bone development, growth, remodeling and repair. Smad1 translocation to the nucleus is observed after the addition of BMP4 (also designated BMP2B), suggesting that BMP4 may play a role in activation of the Smad pathway. BMP is secreted into the extracellular matrix.

Pathways: Steroid Hormone Mediated Signaling Pathway, Regulation of Muscle Cell Differentiation, Tube Formation, Skeletal Muscle Fiber Development