L1CAM antibody

Catalog No. ABIN6937764

The Mouse Monoclonal anti-L1CAM antibody has been validated for ELISA and Coat. It is suitable to detect L1CAM in samples from Human.

Quick Overview for L1CAM antibody (ABIN6937764)

Target: L1CAM (L1 Cell Adhesion Molecule (L1CAM))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This L1CAM antibody is un-conjugated

Application: ELISA, Coating (Coat)

Clone: UJ127

Product Details anti-L1CAM Antibody

Specificity: Recognizes a cell surface protein of 220-240 kDa, identified as L1 cell adhesion molecule. The L1CAM gene, which is located in Xq28, is involved in three distinct conditions: 1) HSAS (hydrocephalus-stenosis of the aqueduct of Sylvius), 2) MASA (mental retardation, aphasia, shuffling gait, and adducted thumbs), and 3) SPG1 (spastic paraplegia). The L1, neural cell adhesion molecule (L1CAM) also plays an important role in axon growth, fasciculation, and neural migration as well as in mediating neuronal differentiation. Expression of L1 protein is restricted to tissues arising from neuroectoderm. This MAb is useful in the identification of primitive neuroectodermal tumors. It binds to tumors of neuroectodermal and glial origin e.g. neuroblastoma and Schwannomas. It does not bind to pediatric or adult brain.

Cross-Reactivity (Details): Human.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Homogenous suspension of 16-week human fetal brain

Isotype: IgG1 kappa

Application Details

Application Notes:

Known_Application: ELISA (For coating, order antibody without BSA), Optimal dilution for a specific application should be determined.

Positive_Control: Neuroblastomas or Schwannomas.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Expiry Date: 24 months

Target Details for L1CAM

Target: L1CAM (L1 Cell Adhesion Molecule (L1CAM))

Alternative Name: L1CAM

Background: CAML1, HSAS1, Hyd, L1 Cell Adhesion Molecule, L1-NCAM, MASA, MIC5, NCAM-L1, Nerve-growth factor-inducible large external glycoprotein, Neural cell adhesion molecule L1, NILE, S10, SPG1,CD171 / NCAM-L1 (Axonal Marker)
Cellular localisation: Cell Surface

Molecular Weight: 220-240kDa

Gene ID: 3897, 52818

UniProt: P32004

Pathways: Synaptic Membrane