TIMP1 antibody (AA 72-82)

Catalog No. ABIN6938575

This anti-TIMP1 antibody is a Mouse Monoclonal antibody detecting TIMP1 in ELISA and Coat. Suitable for Human.

Quick Overview for TIMP1 antibody (AA 72-82) (ABIN6938575)

Target: TIMP1 (TIMP Metallopeptidase Inhibitor 1 (TIMP1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TIMP1 antibody is un-conjugated

Application: ELISA, Coating (Coat)

Clone: 2A5

Product Details anti-TIMP1 Antibody

Binding Specificity: AA 72-82

Specificity: TIMP-1, TIMP-2, TIMP-3 and TIMP-4 (for tissue inhibitor of metalloproteinases -1, -2, -3 and -4) complex with metalloproteinases such as collagenases, gelatinases and stromelysins, resulting in irreversible inactivation of the metalloproteinase. TIMP-1 is identical to EPA (erythroid-potentiation activity). PTH has been shown to be a regulator of TIMP-2 in osteoblastic cells. TIMP-3 may be involved in regulating trophoblastic invasion of the uterus as well as in regulating remodeling of the extracellular matrix during the folding of epithelia, and in the formation, branching and expansion of epithelial tubes. TIMP-4 is most highly expressed in heart tissues. Studies have demonstrated that TIMP1 is useful as a biomarker for early detection of colorectal cancer, outperforming CEA. Additionally, TIMP1 studies have demonstrated its role in CRC tumorigenesis, as well as observing its overexpression in metastatic lymph nodes.

Cross-Reactivity (Details): Human.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: A synthetic peptide (aa 72-82) of human TIMP1 protein (FQALGDAADIR)

Isotype: IgG1 kappa

Application Details

Application Notes:

Known_Application: ELISA (Use Ab at 2-4 μg/mL for coating) (Order Ab without BSA), Optimal dilution for a specific application should be determined.

Positive_Control: 293 cells. Colon Carcinoma.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Expiry Date: 24 months

Target Details for TIMP1

Target: TIMP1 (TIMP Metallopeptidase Inhibitor 1 (TIMP1))

Alternative Name: TIMP1

Background: Collagenase inhibitor, EPO, Erythroid-Potentiating Activity (EPA), Fibroblast collagenase inhibitor, Human Collagenase Inhibitor (HCI), Metalloproteinase inhibitor 1, Tissue Inhibitor of Metalloproteinase 1 (TIMP1),TIMP1 (Marker of Lymph Node Metastasis)
Cellular localisation: Cytoplasmic and Secreted

Molecular Weight: 23kDa

Gene ID: 7076, 522632

UniProt: P01033